Title:
BINDING MOLECULE HAVING NEUTRALIZING ACTIVITY AGAINST SARS-CORONAVIRUS-2
Document Type and Number:
WIPO Patent Application WO/2021/194188
Kind Code:
A1
Abstract:
The present invention relates to a SARS-coronavirus-2 (SARS-CoV-2) binding molecule. More specifically, the present invention relates to a binding molecule which has an excellent binding ability to the spike protein (S protein) on the surface of SARS-coronavirus-2 and has an excellent neutralizing effect on SARS-coronavirus-2, and the binding molecule of the present invention is very useful in diagnosing, preventing or treating SARS-coronavirus infection (COVID-19).
Inventors:
KIM CHEOL-MIN (KR)
SEO JI-MIN (KR)
KIM MIN-SOO (KR)
LEE SOO-YOUNG (KR)
RYU DONG-KYUN (KR)
KIM SUNG-SOON (KR)
LEE JOO-YEON (KR)
KIM KYUNG-CHANG (KR)
YANG JEONG-SUN (KR)
LEE HAN-SAEM (KR)
WOO HYE-MIN (KR)
KIM JUN-WON (KR)
SEO JI-MIN (KR)
KIM MIN-SOO (KR)
LEE SOO-YOUNG (KR)
RYU DONG-KYUN (KR)
KIM SUNG-SOON (KR)
LEE JOO-YEON (KR)
KIM KYUNG-CHANG (KR)
YANG JEONG-SUN (KR)
LEE HAN-SAEM (KR)
WOO HYE-MIN (KR)
KIM JUN-WON (KR)
Application Number:
PCT/KR2021/003498
Publication Date:
September 30, 2021
Filing Date:
March 22, 2021
Export Citation:
Assignee:
CELLTRION INC (KR)
KOREA DISEASE CONTROL AND PREVENTION AGENCY (KR)
KOREA DISEASE CONTROL AND PREVENTION AGENCY (KR)
International Classes:
C07K16/10; A61K39/00; A61P31/14; C12N15/85; G01N33/569
Foreign References:
| US20060240551A1 | 2006-10-26 | |||
| KR20080012449A | 2008-02-12 | |||
| KR102205028B1 | 2021-01-20 | |||
| KR102229225B1 | 2021-03-19 | |||
| KR101076602B1 | 2011-10-26 |
Other References:
WALLS ALEXANDRA C.; PARK YOUNG-JUN; TORTORICI M. ALEJANDRA; WALL ABIGAIL; MCGUIRE ANDREW T.; VEESLER DAVID: "Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein", CELL, ELSEVIER, AMSTERDAM NL, vol. 181, no. 2, 9 March 2020 (2020-03-09), Amsterdam NL, pages 281, XP086136222, ISSN: 0092-8674, DOI: 10.1016/j.cell.2020.02.058
WAN YUSHUN, SHANG JIAN, GRAHAM RACHEL, BARIC RALPH, LI FANG, GALLAGHER TOM: "Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 94, no. 7, US, XP055808633, ISSN: 0022-538X, DOI: 10.1128/JVI.00127-20
WRAPP DANIEL, WANG NIANSHUANG, CORBETT KIZZMEKIA S., GOLDSMITH JORY A., HSIEH CHING-LIN, ABIONA OLUBUKOLA, GRAHAM BARNEY S., MCLEL: "Supplementary Materials for: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation", SCIENCE, 19 February 2020 (2020-02-19), pages 1260 - 1263, XP055829067, Retrieved from the Internet DOI: 10.1126/science.abb2507
JOURNAL OF VIROLOGY, vol. 85, pages 10582
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
XIAOLONG TIAN ET AL., EMERG. MICROBES INFECT., vol. 9, no. 1, 17 February 2020 (2020-02-17), pages 382 - 385
XIAOLONG TIAN ET AL., EMERG MICROBES INFECT, vol. 9, no. 1, 17 February 2020 (2020-02-17), pages 382 - 385
WAN YUSHUN, SHANG JIAN, GRAHAM RACHEL, BARIC RALPH, LI FANG, GALLAGHER TOM: "Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 94, no. 7, US, XP055808633, ISSN: 0022-538X, DOI: 10.1128/JVI.00127-20
WRAPP DANIEL, WANG NIANSHUANG, CORBETT KIZZMEKIA S., GOLDSMITH JORY A., HSIEH CHING-LIN, ABIONA OLUBUKOLA, GRAHAM BARNEY S., MCLEL: "Supplementary Materials for: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation", SCIENCE, 19 February 2020 (2020-02-19), pages 1260 - 1263, XP055829067, Retrieved from the Internet
JOURNAL OF VIROLOGY, vol. 85, pages 10582
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
XIAOLONG TIAN ET AL., EMERG. MICROBES INFECT., vol. 9, no. 1, 17 February 2020 (2020-02-17), pages 382 - 385
XIAOLONG TIAN ET AL., EMERG MICROBES INFECT, vol. 9, no. 1, 17 February 2020 (2020-02-17), pages 382 - 385
Attorney, Agent or Firm:
HANYANG PATENT FIRM (KR)
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