Title:
BIODEGRADABLE POLYURETHANE/UREA COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2004009227
Kind Code:
A3
Abstract:
The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
Inventors:
ADHIKARI RAJU (AU)
GUNATILLAKE PATHIRAJA A (AU)
GUNATILLAKE PATHIRAJA A (AU)
Application Number:
PCT/AU2003/000935
Publication Date:
November 24, 2005
Filing Date:
July 23, 2003
Export Citation:
Assignee:
COMMW SCIENT IND RES ORG (AU)
ADHIKARI RAJU (AU)
GUNATILLAKE PATHIRAJA A (AU)
ADHIKARI RAJU (AU)
GUNATILLAKE PATHIRAJA A (AU)
International Classes:
A61F2/00; A61K31/74; A61L27/18; A61L27/58; A61L31/06; C08G18/10; C08G18/32; C08G18/77; C08G18/80; C08K3/32; C08K5/00; B01J; (IPC1-7): C08G18/32; C08G18/10; C08G18/77; C08K5/00; C08K3/32; A61L27/18; A61L27/58; A61L31/06
Domestic Patent References:
| WO1999002168A1 | 1999-01-21 | |||
| WO2002010247A1 | 2002-02-07 | |||
| WO2000012579A1 | 2000-03-09 |
Foreign References:
| US6376637B1 | 2002-04-23 | |||
| US5886127A | 1999-03-23 | |||
| US20010005738A1 | 2001-06-28 | |||
| EP0837084A2 | 1998-04-22 | |||
| US5981684A | 1999-11-09 | |||
| US5041516A | 1991-08-20 |
Other References:
BRUIN P ET AL: "Design and synthesis of biodegradable poly(ester-urethane) elastomer networks composed of non-toxic building blocks.", MAKROMOL CHEM RAPID COMMUN., vol. 9, no. 8, 1988, pages 589 - 594, XP000857548
HELMINEN A ET AL: "Biodegradable crosslinked polymers based on triethoxysilane terminated polylactide oligomers.", POLYMER ELSEVIER., vol. 42, no. 8, April 2001 (2001-04-01), pages 3345 - 3353, XP004313875
HELMINEN A ET AL: "Biodegradable crosslinked polymers based on triethoxysilane terminated polylactide oligomers.", POLYMER ELSEVIER., vol. 42, no. 8, April 2001 (2001-04-01), pages 3345 - 3353, XP004313875
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