Title:
BIOMARKER FOR COGNITIVE IMPAIRMENT DISORDERS AND DETECTION METHOD FOR COGNITIVE IMPAIRMENT DISORDERS USING SAID BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2019/012667
Kind Code:
A1
Abstract:
Provided are: a method for detecting cognitive impairment disorders including mild cognitive impairment and Alzheimer's disease using a protein that is present in different amounts in subjects with normal cognitive function and patients with cognitive impairment disorders, and a peptide of said protein; and a biomarker comprising said protein and said peptide and for detecting cognitive impairment disorders including mild cognitive impairment and Alzheimer's disease. The present invention is: a biomarker for diagnosing cognitive impairment disorders and comprising the peptide THRB, which is a prothrombin precursor protein in SEQ ID NO: 1 or a peptide thereof and comprises the amino acid sequence represented by SEQ ID NO: 2; a diagnosis method for cognitive impairment disorders using the biomarker; an antigen peptide represented by SEQ ID NO: 3 for creating a THRB peptide–specific antibody to be used in the diagnosis method; and a cognitive impairment disorder diagnosis kit containing the THRB peptide–specific antibody.
Inventors:
UCHIDA KAZUHIKO (JP)
MENO KOHJI (JP)
SUZUKI HIDEAKI (JP)
MENO KOHJI (JP)
SUZUKI HIDEAKI (JP)
Application Number:
PCT/JP2017/025607
Publication Date:
January 17, 2019
Filing Date:
July 13, 2017
Export Citation:
Assignee:
MCBI INC (JP)
UCHIDA KAZUHIKO (JP)
UCHIDA KAZUHIKO (JP)
International Classes:
G01N33/68
Domestic Patent References:
| WO2010134308A1 | 2010-11-25 | |||
| WO2012086197A1 | 2012-06-28 |
Foreign References:
| JP2012132808A | 2012-07-12 | |||
| JP2004505609A | 2004-02-26 | |||
| JP2010271078A | 2010-12-02 | |||
| US20120283114A1 | 2012-11-08 | |||
| JP2004333274A | 2004-11-25 | |||
| JP2006308533A | 2006-11-09 |
Other References:
KAZUHIKO UCHIDA: "Ninchisho Mattanashi! Ninchisho no Soki Hakken -Kainyu no Tameno MCI Oyobi Preclinical AD no Ketsueki Biomarker eno Kita i", JOURNAL OF CLINICAL LABORATORY MEDICINE, vol. 60, no. 13, 15 December 2016 (2016-12-15), pages 1530 - 1536, XP009518949, ISSN: 0485-1420
KAZUHIKO UCHIDA: "Ninchisho to Omics Kaiseki Keido Ninchi Shogai to Alzheimer-byo no Ketsueki Biomarker", DEMENTIA JAPAN, vol. 27, no. 3, 15 September 2013 (2013-09-15), pages 277 - 288, XP009518933
KAZUHIKO UCHIDA: "Ninchisho Peptidomics", DEMENTIA JAPAN, vol. 26, no. 4, 25 October 2012 (2012-10-25), pages 438, XP009518932
"YOKUWAKARU ALZHEIMER'S DISEASE", 2004, NAGAI SHOTEN
N. BENKIRANE ET AL., J. BIOL. CHEM., vol. 268, 1993, pages 26279 - 26285
See also references of EP 3654038A4
KAZUHIKO UCHIDA: "Ninchisho to Omics Kaiseki Keido Ninchi Shogai to Alzheimer-byo no Ketsueki Biomarker", DEMENTIA JAPAN, vol. 27, no. 3, 15 September 2013 (2013-09-15), pages 277 - 288, XP009518933
KAZUHIKO UCHIDA: "Ninchisho Peptidomics", DEMENTIA JAPAN, vol. 26, no. 4, 25 October 2012 (2012-10-25), pages 438, XP009518932
"YOKUWAKARU ALZHEIMER'S DISEASE", 2004, NAGAI SHOTEN
N. BENKIRANE ET AL., J. BIOL. CHEM., vol. 268, 1993, pages 26279 - 26285
See also references of EP 3654038A4
Attorney, Agent or Firm:
WATANABE Kaoru (JP)
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