Title:
BIOMARKER COMPOSITION FOR DIAGNOSING DEGENERATIVE BRAIN DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/124457
Kind Code:
A1
Abstract:
The present invention relates to a biomarker composition for diagnosing degenerative brain diseases. Specifically, the present invention provides a biomarker composition for diagnosing degenerative brain diseases comprising main markers and sub-markers as active ingredients by which, in the blood serum of patients with mild cognitive impairment/stage 1 dementia and stage 2 dementia/stage 3 dementia, the levels of main markers amyloid beta 40 (Aβ40), tau, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) were measured to be significantly higher than those of a normal control group, the levels of brain-derived nerve growth factor (BDNF) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) were measured to be significantly low, the levels of phospho-tau (AT180) and homocystein (HCY) were measured to be significantly high, and the level of peptidyl-prolyl isomerase (Pin1) was confirmed to be significantly low.
Inventors:
JO SEO YUN (KR)
Application Number:
PCT/KR2020/018263
Publication Date:
June 16, 2022
Filing Date:
December 14, 2020
Export Citation:
Assignee:
JHK MEDICAL SCIENCE INC (KR)
International Classes:
G01N33/68
Foreign References:
| US20150268252A1 | 2015-09-24 | |||
| US20040014142A1 | 2004-01-22 |
Other References:
SCHMIDT FRANK MARTIN; MERGL ROLAND; STACH BARBARA; JAHN INA; GERTZ HERMANN-JOSEF; SCHÖNKNECHT PETER : "Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease", NEUROSCIENCE LETTERS, vol. 570, 16 April 2014 (2014-04-16), AMSTERDAM, NL , pages 81 - 85, XP029024058, ISSN: 0304-3940, DOI: 10.1016/j.neulet.2014.04.007
SESHADRI SUDHA: "Plasma homocysteine as a risk factor for dementia and Alzheimer`s disease", NEW ENGLAND JOURNAL OF MEDICINE, vol. 346, no. 7, 1 January 2002 (2002-01-01), pages 476 - 483, XP055941441
WANG LONG, ZHOU YING, CHEN DONGMEI, LEE TAE HO: "Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, no. 355, pages 1 - 12, XP055941443, DOI: 10.3389/fcell.2020.00355
KIM KAYOUNG, KIM MIN-JI, KIM DA WON, KIM SU YEONG, PARK STEVE, PARK CHAN BEUM: "Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma", NATURE COMMUNICATIONS, vol. 11, no. 119, 1 December 2020 (2020-12-01), pages 1 - 9, XP055941448, DOI: 10.1038/s41467-019-13901-z
SESHADRI SUDHA: "Plasma homocysteine as a risk factor for dementia and Alzheimer`s disease", NEW ENGLAND JOURNAL OF MEDICINE, vol. 346, no. 7, 1 January 2002 (2002-01-01), pages 476 - 483, XP055941441
WANG LONG, ZHOU YING, CHEN DONGMEI, LEE TAE HO: "Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, no. 355, pages 1 - 12, XP055941443, DOI: 10.3389/fcell.2020.00355
KIM KAYOUNG, KIM MIN-JI, KIM DA WON, KIM SU YEONG, PARK STEVE, PARK CHAN BEUM: "Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma", NATURE COMMUNICATIONS, vol. 11, no. 119, 1 December 2020 (2020-12-01), pages 1 - 9, XP055941448, DOI: 10.1038/s41467-019-13901-z
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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