Title:
BIOMARKER COMPOSITION FOR DIAGNOSING SMALL CELL LUNG CANCER, CONTAINING EXOSOME-DERIVED MIRNAS AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/035082
Kind Code:
A1
Abstract:
The present invention relates to a biomarker composition for diagnosing small cell lung cancer, containing exosome-derived miRNAs as an active ingredient. Small cell lung cancer diagnosis and prognosis prediction accuracy has been analyzed using, individually or in combination, 7 miRNAs, which have been identified through analysis of miRNAs in exosomes separated from a normal group and a small cell lung cancer patient group and of which expression is specifically increased or decreased in the small cell lung cancer patient group, such that it has been identified that an miRNA combination consisting of miR-200b-3P, miR-3124-5p and miR-92b-5p exhibits an excellent small cell lung cancer diagnosis and prognosis prediction effect, and thus the composition can be effectively used as a biomarker composition for small cell lung cancer diagnosis or prognosis prediction.
Inventors:
RHO JIN KYUNG (KR)
LEE JAE CHEOL (KR)
CHOI CHANG-MIN (KR)
KIM DONG HA (KR)
JI WONJUN (KR)
LEE JAE CHEOL (KR)
CHOI CHANG-MIN (KR)
KIM DONG HA (KR)
JI WONJUN (KR)
Application Number:
PCT/KR2023/011690
Publication Date:
February 15, 2024
Filing Date:
August 08, 2023
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C12Q1/6886
Foreign References:
| CN102899390A | 2013-01-30 | |||
| US20200255906A1 | 2020-08-13 | |||
| KR20200019849A | 2020-02-25 |
Other References:
박효정. 소세포폐암 유래 exosomal miRNAs을 활용한 진단 및 예후 예측. 울산대학교 석사학위 학위논문. pp. 1-31, February 2022 (PARK, Hyo-Jung. Clinical application of exosomal miRNAs in small cell lung cancer. Master's thesis, University of Ulsan.)
LI MING, SHAN WULIN, HONG BO, ZOU JINGLU, LI HONG, HAN DANDAN, ZHANG YANG, LI LAILING, LI DAN, LIN WENCHU: "Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 10, no. 1, 29 July 2020 (2020-07-29), US , pages 12705, XP093138223, ISSN: 2045-2322, DOI: 10.1038/s41598-020-69615-6
LI MING, SHAN WULIN, HONG BO, ZOU JINGLU, LI HONG, HAN DANDAN, ZHANG YANG, LI LAILING, LI DAN, LIN WENCHU: "Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 10, no. 1, 29 July 2020 (2020-07-29), US , pages 12705, XP093138223, ISSN: 2045-2322, DOI: 10.1038/s41598-020-69615-6
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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