Title:
BIOMARKER FOR DIAGNOSING ACUTE TUMOR RESPONSE OF UTERINE CERVICAL CANCER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/103027
Kind Code:
A1
Abstract:
The present invention relates to a biomarker for diagnosing acute tumor response of a uterine cervical cancer, and the use thereof. More particularly, as a result of analyzing microRNAs included inside exosomes isolated from the blood of uterine cervical cancer patients receiving anticancer radiotherapy before/after the treatment, microRNA 92a-1-5p(hsa-miR-92a-1-5p), microRNA 3960(hsa-miR-3960), microRNA 202-5p(hsa-miR-202-5p), microRNA 3928-5p(hsa-miR-3928-5p) and microRNA 574-3p(hsa-miR-574-3p) are discovered as microRNAs associated with acute tumor response (AR) of uterine cervical cancer and are confirmed to be associated with mRNA of Diablo homolog (DIABLO), mRNA of ubiquitin C (UBC) and mRNA of SIN3 transcription regulator family member A (SIN3A). Therefore, the present invention provides a biomarker composition for diagnosing acute tumor response of uterine cervical cancer comprising the microRNAs and mRNAs, a composition for diagnosing acute tumor response of uterine cervical cancer, a kit for diagnosing acute tumor response of uterine cervical cancer, and an information providing method for diagnosing acute tumor response of uterine cervical cancer.
Inventors:
CHO O YEON (KR)
Application Number:
PCT/KR2021/015250
Publication Date:
May 19, 2022
Filing Date:
October 27, 2021
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C12Q1/6886
Foreign References:
| US20130184175A1 | 2013-07-18 | |||
| US20100234445A1 | 2010-09-16 |
Other References:
ARELLANO-LLAMAS ABRIL; GARCIA FRANCISCO J; PEREZ DELIA; CANTU DAVID; ESPINOSA MAGALI; DE LA GARZA JAIME G; MALDONADO VILMA; MELEND: "High Smac/DIABLO expression is associated with early local recurrence of cervical cancer", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 6, no. 1, 26 October 2006 (2006-10-26), LONDON, GB , pages 256, XP021023042, ISSN: 1471-2407, DOI: 10.1186/1471-2407-6-256
LUO SHENGTIAN, LI NA, YU SHAOHUA, CHEN LICHUN, LIU CHUNYING, RONG JIAWEI: "MicroRNA-92a promotes cell viability and invasion in cervical cancer via directly targeting Dickkopf-related protein 3", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 14, no. 2, 1 August 2017 (2017-08-01), GR , pages 1227 - 1234, XP055929475, ISSN: 1792-0981, DOI: 10.3892/etm.2017.4586
ZHOU CHUANYI, SHEN LIANGFANG, MAO LEI, WANG BING, LI YANG, YU HUIZHI: "miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 458, no. 1, 1 February 2015 (2015-02-01), Amsterdam NL , pages 63 - 69, XP055929474, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2015.01.066
LUO SHENGTIAN, LI NA, YU SHAOHUA, CHEN LICHUN, LIU CHUNYING, RONG JIAWEI: "MicroRNA-92a promotes cell viability and invasion in cervical cancer via directly targeting Dickkopf-related protein 3", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 14, no. 2, 1 August 2017 (2017-08-01), GR , pages 1227 - 1234, XP055929475, ISSN: 1792-0981, DOI: 10.3892/etm.2017.4586
ZHOU CHUANYI, SHEN LIANGFANG, MAO LEI, WANG BING, LI YANG, YU HUIZHI: "miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 458, no. 1, 1 February 2015 (2015-02-01), Amsterdam NL , pages 63 - 69, XP055929474, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2015.01.066
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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