Title:
BIOMARKER, METHOD FOR SEARCHING DISEASE-RELATED GENE, AND RENAL CANCER MARKER
Document Type and Number:
WIPO Patent Application WO/2018/079689
Kind Code:
A1
Abstract:
Provided is a method wherein an affected tissue and a normal tissue obtained from the vicinity of the affected tissue are left at rest in a culture medium, and a disease-specific biomarker is searched for in an exudate therefrom. By means of said method, a biomarker specific to renal cell cancer has been discovered.
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Inventors:
UEDA KOJI (JP)
OHNISHI NAOMI (JP)
NONOMURA NORIO (JP)
UEMURA MOTOHIDE (JP)
FUJITA KAZUTOSHI (JP)
TSUJIKAWA KAZUTAKE (JP)
JINGUSHI KENTAROU (JP)
OHNISHI NAOMI (JP)
NONOMURA NORIO (JP)
UEMURA MOTOHIDE (JP)
FUJITA KAZUTOSHI (JP)
TSUJIKAWA KAZUTAKE (JP)
JINGUSHI KENTAROU (JP)
Application Number:
PCT/JP2017/038812
Publication Date:
May 03, 2018
Filing Date:
October 26, 2017
Export Citation:
Assignee:
JAPANESE FOUND FOR CANCER RES (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
G01N33/68; C12Q1/68; G01N33/15; G01N33/50; G01N33/574; G01N33/92
Domestic Patent References:
| WO2015005965A1 | 2015-01-15 |
Foreign References:
| JP2012508577A | 2012-04-12 | |||
| JP2013544361A | 2013-12-12 | |||
| EP2955232A1 | 2015-12-16 | |||
| JP2016086678A | 2016-05-23 | |||
| JP2013140030A | 2013-07-18 |
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JINGUJI, KENTARO: "P-3192 Analysis of extracellular vesicles derived from clear cell type renal cell carcinoma tissue", THE 74TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION; OCTOBER 8-10, 2015, vol. 74, 2015, pages P-3192, XP009519184
RAN GUO: "Proteins Secreted by Lung Adenocarcinoma Cells ― Identification of Candidate Diagnosis Markers from Culture Supernatants of Dissected Tumor Tissue ", JAPANESE JOURNAL OF LUNG CANCER, vol. 50, no. 2, 1 January 2010 (2010-01-01), pages 141 - 150, XP009515257, DOI: 10.2482/haigan.50.141
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MORITA, TAKUYA: "Identification of exosome surface marker derived from Ewing sarcoma cell applicable to liquid biopsy", THE JOURNAL OF JAPANESE ORTHOPAEDIC SURGICAL SOCIETY, vol. 89, no. 8, 10 September 2015 (2015-09-10), pages 1796 2 - 7-22, XP009516050
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KIYOMI, ANNA: "Immunologic substance secreted from 3-dimensional human breast cancer, and effects on behavior of suppressor T cell thereof", ABSTRACTS OF THE PHARMACEUTICAL SOCIETY OF JAPAN ANNUAL MEETING, vol. 134, 2014, pages 30PMM-89, XP009515162
BONIFATI, C ET AL: "IL -lalpha, IL -lbeta and psoriasis: conflicting results in the literature. Opposite behavior of the two cytokines in lessional or non-lessional extracts of whole skin", J BIOL REGUL HOMEOST AGENTS, vol. 11, no. 4, 1997, pages 133 - 136, XP009179746, ISSN: 0393-974X
KIYOHARA, YUMIKO: "Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer", CANCER SCIENCE, vol. 107, no. 4, April 2016 (2016-04-01), pages 452 - 460, XP055477668, ISSN: 1347-9032, DOI: 10.1111/cas.12898
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NAGAYAMA, SATOSHI: "Search for biomarkers for diagnosis of colorectal cancer by comprehensive analysis of resected tissue culture secretion exosome", JOURNAL OF JAPAN SURGICAL SOCIETY, vol. 117, 27 April 2017 (2017-04-27), pages 1, XP009518614
S. MURAOKA, R. FUJII, S. NAGAYAMA, K. UEDA: "Proteome-wide profiling of viable colorectal cancer tissue-derived extracellular vesicle", ABSTRACTS FOR ANNUAL MEETING OF JAPANESE PROTEOMICS SOCIETY - JPROS 2017 CONFERENCE (JHUPO 15TH CONFERENCE), JULY 26-28 2017, vol. 2017, 26 July 2017 (2017-07-26), pages 148, XP009518018, DOI: 10.14889/jhupo.2017.0.148.0
KAHLERT, C.KALLURI, R., J. MOL. MED., vol. 91, no. 4, 2013, pages 431 - 437
AN, T. ET AL., J. EXTRACELL. VESICLES, vol. 4, 2015, pages 27522
PEINADO, H. ET AL., NAT. MED., vol. 18, no. 6, 2012, pages 883 - 891
COSTA-SLIVA, B. ET AL., NAT. CELL BIOL., vol. 17, no. 6, 2015, pages 816 - 826
HOSHINO, A. ET AL., NATURE, vol. 527, no. 7578, 2015, pages 329 - 335
LASSER, C. ET AL., J. VIS. EXP., vol. 59, 2012, pages e3037
GEISSLER, K. ET AL., ONCOIMMUNOLOGY, vol. 4, 2015, pages e985082
TELTSH, 0. ET AL., ONCOTARGET, vol. 32, 2015, pages 33191 - 33205
GULDUR, M. E. ET AL., J. PAK. MED. ASSOC., vol. 3, 2014, pages 300 - 303
BUSSOLATI, B. ET AL., FASEB J., vol. 17, no. 9, 2003, pages 1159 - 1161
WIKLANDER, O.P. ET AL., J. EXTRACELL. VESICLES, vol. 4, 2015, pages 26316
TOMINAGA, N. ET AL., ADV. DRUG DELIV. REV., vol. 95, 2015, pages 50 - 55
LAI, C. P. ET AL., ACS NANO., vol. 8, no. 1, 2014, pages 483 - 494
GRUENWALD, V. ET AL., BMC CANCER, vol. 10, 2010, pages 695
VROLING, L. ET AL., ANGIOGENESIS, vol. 12, no. 1, 2009, pages 69 - 79
DEL PUERTO-NEVADO, L. ET AL., BR. J. CANCER, vol. 110, 2014, pages 2700 - 2707
SHANKHAJIT, D. ET AL., INTERNATIONAL JOURNAL OF NUTRITION, PHARMACOLOGY, NEUROLOGICAL DISEASES, vol. 2, 2012, pages 3 - 7
JINGUJI, KENTARO: "P-3192 Analysis of extracellular vesicles derived from clear cell type renal cell carcinoma tissue", THE 74TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION; OCTOBER 8-10, 2015, vol. 74, 2015, pages P-3192, XP009519184
RAN GUO: "Proteins Secreted by Lung Adenocarcinoma Cells ― Identification of Candidate Diagnosis Markers from Culture Supernatants of Dissected Tumor Tissue ", JAPANESE JOURNAL OF LUNG CANCER, vol. 50, no. 2, 1 January 2010 (2010-01-01), pages 141 - 150, XP009515257, DOI: 10.2482/haigan.50.141
GUO RAN: "Proteome analysis for culture supernatant of primary pulmonary adenocarcinoma tumor tissue", THE JOURNAL OF TOKYO MEDICAL UNIVERSITY, vol. 67, no. 4, 30 October 2009 (2009-10-30), pages 502, XP009504196
MORITA, TAKUYA: "Identification of exosome surface marker derived from Ewing sarcoma cell applicable to liquid biopsy", THE JOURNAL OF JAPANESE ORTHOPAEDIC SURGICAL SOCIETY, vol. 89, no. 8, 10 September 2015 (2015-09-10), pages 1796 2 - 7-22, XP009516050
KAWAKAMI, FURUO: "Proteomics of biomarker: Proteome statistic analysis using liquid chromatography/tandem mass spectrometry, and applications thereof", JSBSM LETT, vol. 35, no. 1, 25 March 2010 (2010-03-25), pages 4 - 12, XP009515258, ISSN: 1881-5464
ZWICKL, H ET AL : "A novel technique to specifically analyze the secretome of cells and tissues", ELECTROPHORESIS, vol. 26, no. 14, 1 July 2005 (2005-07-01), pages 2779 - 2785, XP055598872, ISSN: 0173-0835, DOI: 10.1002/elps.200410387
KIYOMI, ANNA: "Immunologic substance secreted from 3-dimensional human breast cancer, and effects on behavior of suppressor T cell thereof", ABSTRACTS OF THE PHARMACEUTICAL SOCIETY OF JAPAN ANNUAL MEETING, vol. 134, 2014, pages 30PMM-89, XP009515162
BONIFATI, C ET AL: "IL -lalpha, IL -lbeta and psoriasis: conflicting results in the literature. Opposite behavior of the two cytokines in lessional or non-lessional extracts of whole skin", J BIOL REGUL HOMEOST AGENTS, vol. 11, no. 4, 1997, pages 133 - 136, XP009179746, ISSN: 0393-974X
KIYOHARA, YUMIKO: "Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer", CANCER SCIENCE, vol. 107, no. 4, April 2016 (2016-04-01), pages 452 - 460, XP055477668, ISSN: 1347-9032, DOI: 10.1111/cas.12898
BERGMAN A-C ET AL: "Identification of gel-separated tumor marker proteins by mass spectrometry", ELECTROPHORESIS , vol. 21, no. 3, 1 February 2000 (2000-02-01), pages 679 - 686, XP000923086, ISSN: 0173-0835, DOI: 10.1002/(SICI)1522-2683(20000201)21:3<679::AID-ELPS679>3.0.CO;2-A
NAGAYAMA, SATOSHI: "Search for biomarkers for diagnosis of colorectal cancer by comprehensive analysis of resected tissue culture secretion exosome", JOURNAL OF JAPAN SURGICAL SOCIETY, vol. 117, 27 April 2017 (2017-04-27), pages 1, XP009518614
S. MURAOKA, R. FUJII, S. NAGAYAMA, K. UEDA: "Proteome-wide profiling of viable colorectal cancer tissue-derived extracellular vesicle", ABSTRACTS FOR ANNUAL MEETING OF JAPANESE PROTEOMICS SOCIETY - JPROS 2017 CONFERENCE (JHUPO 15TH CONFERENCE), JULY 26-28 2017, vol. 2017, 26 July 2017 (2017-07-26), pages 148, XP009518018, DOI: 10.14889/jhupo.2017.0.148.0
KAHLERT, C.KALLURI, R., J. MOL. MED., vol. 91, no. 4, 2013, pages 431 - 437
AN, T. ET AL., J. EXTRACELL. VESICLES, vol. 4, 2015, pages 27522
PEINADO, H. ET AL., NAT. MED., vol. 18, no. 6, 2012, pages 883 - 891
COSTA-SLIVA, B. ET AL., NAT. CELL BIOL., vol. 17, no. 6, 2015, pages 816 - 826
HOSHINO, A. ET AL., NATURE, vol. 527, no. 7578, 2015, pages 329 - 335
LASSER, C. ET AL., J. VIS. EXP., vol. 59, 2012, pages e3037
GEISSLER, K. ET AL., ONCOIMMUNOLOGY, vol. 4, 2015, pages e985082
TELTSH, 0. ET AL., ONCOTARGET, vol. 32, 2015, pages 33191 - 33205
GULDUR, M. E. ET AL., J. PAK. MED. ASSOC., vol. 3, 2014, pages 300 - 303
BUSSOLATI, B. ET AL., FASEB J., vol. 17, no. 9, 2003, pages 1159 - 1161
WIKLANDER, O.P. ET AL., J. EXTRACELL. VESICLES, vol. 4, 2015, pages 26316
TOMINAGA, N. ET AL., ADV. DRUG DELIV. REV., vol. 95, 2015, pages 50 - 55
LAI, C. P. ET AL., ACS NANO., vol. 8, no. 1, 2014, pages 483 - 494
GRUENWALD, V. ET AL., BMC CANCER, vol. 10, 2010, pages 695
VROLING, L. ET AL., ANGIOGENESIS, vol. 12, no. 1, 2009, pages 69 - 79
DEL PUERTO-NEVADO, L. ET AL., BR. J. CANCER, vol. 110, 2014, pages 2700 - 2707
SHANKHAJIT, D. ET AL., INTERNATIONAL JOURNAL OF NUTRITION, PHARMACOLOGY, NEUROLOGICAL DISEASES, vol. 2, 2012, pages 3 - 7
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
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