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Title:
BIOMARKERS FOR COLORECTAL CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/109876
Kind Code:
A1
Abstract:
A method of treating a colorectal cancer in an individual, comprising administering to the individual an effective amount of a CDK7 inhibitor, wherein the individual is selected for treatment on the basis of having one or more drug sensitive aberrations in one or a plurality of drug sensitive genes, and a method of identifying an individual having a colorectal cancer who may benefit from a treatment comprising administration of a CDK7 inhibitor, the method comprising detecting in a sample from the individual one or more drug sensitive aberrations in one or a plurality of drug sensitive genes. Correspondingly,a plurality of capture nucleic acid molecules,a system and a non-trassitory computer readble storage medium are provided.

Inventors:
YUAN PENGFEI (CN)
JIN MING (CN)
ZHANG YONGJIAN (CN)
SHEN HONGYAN (CN)
YANG LING (CN)
LIU NA (CN)
SU MEIHUA (CN)
ZHENG YARU (CN)
LI YULAN (CN)
Application Number:
PCT/CN2022/139152
Publication Date:
June 22, 2023
Filing Date:
December 14, 2022
Export Citation:
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Assignee:
EDIGENE THERAPEUTICS BEIJING INC (CN)
International Classes:
C12Q1/6886; G01N33/574
Domestic Patent References:
WO2020093006A12020-05-07
WO2021174052A12021-09-02
WO2021087138A12021-05-06
WO2020093011A12020-05-07
WO2021243280A22021-12-02
Foreign References:
CN102473202A2012-05-23
CN107427521A2017-12-01
CN110656179A2020-01-07
US20190055248A12019-02-21
Other References:
WANG, J ET AL.: "Antitumor effects of a covalent cyclin-dependent kinase 7 inhibitor in colorectal cancer", ANTI-CANCER DRUGS, 31 December 2019 (2019-12-31), XP009546945
Attorney, Agent or Firm:
BEIJING CAIHE LAW FIRM (CN)
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