Title:
BIOSYNTHESIS-BASED PREPARATION METHOD FOR STRUCTURAL MATERIAL OF HUMAN BODY
Document Type and Number:
WIPO Patent Application WO/2024/016740
Kind Code:
A1
Abstract:
Provided is a biosynthesis-based preparation method for a structural material of the human body. A polypeptide of the present application contains the structure of a C-terminal region of (repeating unit)n or (repeating unit)n-; the repeating unit contains an amino acid sequence as shown in SEQ ID NO. 1. Recombinant type V humanized collagen prepared in the present application has high activity in promoting cell adhesion, and does not cause an immune response when applied to the human body; moreover, the preparation method is novel, allows for large-scale production of the recombinant type V humanized collagen, and is widely used in the preparation of structural materials of the human body. The application field comprises preparation of high-end medical devices, such as biological dressings, human body biomimetic materials, plastic-beauty materials, organoid culture, cardiovascular stents, coatings, tissue injection filling, ophthalmic materials, gynecological biomaterials, nerve repair and regeneration, liver tissue and vessel repair and regeneration, and 3D printing of artificial organ biomaterials.
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Inventors:
YANG XIA (CN)
ZHANG XINGDONG (CN)
WANG YUNBING (CN)
YANG LI (CN)
HE ZHENRUI (CN)
ZHANG XINGDONG (CN)
WANG YUNBING (CN)
YANG LI (CN)
HE ZHENRUI (CN)
Application Number:
PCT/CN2023/087212
Publication Date:
January 25, 2024
Filing Date:
April 10, 2023
Export Citation:
Assignee:
SHANXI JINBO BIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/78; A23L33/17; A61K8/65; A61K38/39; A61K47/42; A61L15/32; A61L27/24; A61L31/04; A61Q19/00; C07K1/18; C07K19/00; C12N1/21; C12N15/12; C12N15/63; C12N15/70
Foreign References:
| CN112745385A | 2021-05-04 | |||
| CN113476593A | 2021-10-08 | |||
| US20210002349A1 | 2021-01-07 | |||
| CN114316030A | 2022-04-12 |
Other References:
LI YANG, ZHU CHENHUI, FAN DAIDI: "Green biological manufacture and application of recombinant collagen", CHEMICAL INDUSTRY AND ENGINEERING PROGRESS, BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY, MEMBER OF CHINESE ACADEMY OF ENGINEERING, PROFESSOR, CHINA, vol. 40, no. 3, 5 March 2021 (2021-03-05), pages 1262 - 1275, XP093080821, ISSN: 1000-6613, DOI: 10.16085/j.issn.1000-6613.2020-2109
M HATAI: "Effects of fibronectin-type V collagen recombinant fusion protein on cell adhesion and cell proliferation", CELL STRUCT FUNCT., vol. 17, no. 5, 31 October 1992 (1992-10-31), XP055882716, DOI: 10.1247/csf.17.293
M HATAI: "Effects of fibronectin-type V collagen recombinant fusion protein on cell adhesion and cell proliferation", CELL STRUCT FUNCT., vol. 17, no. 5, 31 October 1992 (1992-10-31), XP055882716, DOI: 10.1247/csf.17.293
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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