BISPECIFIC ANTIBODY AND APPLICATION THEREOF - SUNSHINE LAKE PHARMA CO LTD

Title:

BISPECIFIC ANTIBODY AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/186000

Kind Code:

A1

Abstract:

Disclosed in the present invention are a bispecific antibody and an application thereof. The antibody comprises: a first peptide chain comprising an antibody first heavy chain variable region and a heavy chain constant region, wherein the heavy chain constant region comprises a CH1 region, a first hinge region, and a first Fc region; a second peptide chain comprising an antibody first light chain variable region and a light chain constant region; and a third peptide chain comprising a single chain antibody, a second hinge region, and a second Fc region, wherein the antibody heavy chain variable region and the antibody light chain variable region have a first antigen binding activity; the single chain antibody has a second antigen binding activity; the first peptide chain is connected to the second peptide chain by means of a disulfide bond; the first hinge region is connected to the second hinge region by means of a disulfide bond; and the first Fc region is connected to the second Fc region by means of a Knobs-into-hole structure. The antibody can effectively inhibit tumor growth and reduce the possibility of cytokine storm, and thus has high safety.

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Inventors:

LIN SHUSHAN (CN)
LI XIANG (CN)
DONG JUNJI (CN)
PENG JU (CN)
JIA XINGFAN (CN)
ZHOU LINJUN (CN)
ZHANG KUO (CN)
REN ZHIHENG (CN)
LI KAIFENG (CN)
XU YUCHENG (CN)
QU DAIXIN (CN)
CHEN XIXIN (CN)
LI LIJIA (CN)
KANG NING (CN)
CHEN LIMO (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)

Application Number:

PCT/CN2023/085032

Publication Date:

October 05, 2023

Filing Date:

March 30, 2023

Export Citation:

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Assignee:

SUNSHINE LAKE PHARMA CO LTD (CN)

International Classes:

C07K16/46; A61K39/395; A61P35/00; C12N15/13

Other References:

ZHANG FENG, WANG KAI-QIN, WANG LAN: "Development in Bispecific Antibody", CHINESE JOURNAL OF PHARMACEUTICAL ANALYSIS, ZHONGGUO YAOXUEHUI, BEIJING, CN, vol. 39, no. 1, 31 January 2019 (2019-01-31), CN , pages 78 - 85, XP009522265, ISSN: 0254-1793, DOI: 10.16155/j.0254-1793.2019.01.10

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