Title:
BISPECIFIC ANTIBODY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/000530
Kind Code:
A1
Abstract:
Provided are a bispecific antibody and a preparation method therefor. The antibody comprises structural domains capable of binding to CD20 and CD3, and a heterodimer Fc region. The structural domains capable of binding to CD20 and CD3 are each independently selected from a Fab region, a ScFv region, or an sDab region. The bispecific antibody targets CD20 and CD3, and mediates T cell-specific killing of tumor cells.
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Inventors:
ZHANG WENJUN (CN)
LI FENG (CN)
HUA YANAN (CN)
LIU JIAXI (CN)
FANG CHUNHUA (CN)
LI FENG (CN)
HUA YANAN (CN)
LIU JIAXI (CN)
FANG CHUNHUA (CN)
Application Number:
PCT/CN2019/126066
Publication Date:
January 07, 2021
Filing Date:
December 17, 2019
Export Citation:
Assignee:
EXCELMAB INC (CN)
International Classes:
C07K16/46; A61K39/395; A61P35/00; A61P35/02; C07K16/18; C12N15/13
Domestic Patent References:
| WO2017034770A1 | 2017-03-02 |
Foreign References:
| CN107660214A | 2018-02-02 | |||
| CN107660214A | 2018-02-02 | |||
| CN107660214A | 2018-02-02 | |||
| CN101544694A | 2009-09-30 | |||
| CN101544694A | 2009-09-30 | |||
| US20140093454A1 | 2014-04-03 | |||
| CN201810263832A | 2018-03-27 |
Other References:
"UniProt Entry", Database accession no. P0423
"UniProt", Database accession no. P11836
SAMBROOK JF, E. F. ET AL.: "Molecular cloning: a laboratory manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3967713A4
"UniProt", Database accession no. P11836
SAMBROOK JF, E. F. ET AL.: "Molecular cloning: a laboratory manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3967713A4
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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