Title:
BISPECIFIC ANTIBODY SPECIFICALLY BINDING TO IL-17A AND TNF-α
Document Type and Number:
WIPO Patent Application WO/2020/218791
Kind Code:
A1
Abstract:
The present invention relates to a bispecific antibody specifically binding to IL-17A and TNF-α, and uses thereof. The bispecific antibody or an antigen binding fragment thereof, according to the present invention, exhibits high specificity with respect to IL-17A and TNF-α and an excellent neutralization ability compared to a conventional monospecific antibody, while quickly inhibiting inflammation and an immune reaction by inhibiting IL-17 and TNF-α at the same time, and, thereby, has the benefit of improving a treatment effect and decreasing an administration amount.
Inventors:
YOON JAE BONG (KR)
JEON EUN YOUNG (KR)
LEE JIN SIL (KR)
BAEK GI SUN (KR)
YOO SEOK HO (KR)
LIM JUNG CHAE (KR)
PARK BUM-CHAN (KR)
CHO YOUNG-GYU (KR)
PARK YOUNG WOO (KR)
JEON EUN YOUNG (KR)
LEE JIN SIL (KR)
BAEK GI SUN (KR)
YOO SEOK HO (KR)
LIM JUNG CHAE (KR)
PARK BUM-CHAN (KR)
CHO YOUNG-GYU (KR)
PARK YOUNG WOO (KR)
Application Number:
PCT/KR2020/005213
Publication Date:
October 29, 2020
Filing Date:
April 20, 2020
Export Citation:
Assignee:
Y BIOLOGICS INC (KR)
International Classes:
C07K16/24; A61K39/00; A61K47/68; A61P37/00; C07K16/46
Domestic Patent References:
| WO2014137961A1 | 2014-09-12 |
Foreign References:
| US20150147327A1 | 2015-05-28 | |||
| US20170218092A1 | 2017-08-03 | |||
| KR20150113199A | 2015-10-07 | |||
| KR20110016958A | 2011-02-18 | |||
| KR20180095719A | 2018-08-27 |
Other References:
BIOTHERAPY, vol. 3, no. 2, 1991, pages 103 - 11
ANNU REV IMMUNOL., vol. 14, 1996, pages 97 - 440
INFLAMM BOWEL DIS., vol. 5, no. 2, 1999, pages 19 - 33
RHEUMATOLOGY (OXFORD, vol. 46, no. 7, 2007, pages 1153 - 6
ANN RHEUM DIS., vol. 65, no. 6, 2006, pages 746 - 52
JEXPMED, vol. 183, no. 6, 1996, pages 2593 - 603
J INVEST DERMATOL., vol. 131, no. 3, 2011, pages 677 - 87
NENGL J MED, vol. 361, no. 9, 2009, pages 888 - 98
J INVEST DERMATOL, vol. 133, no. 1, 2013, pages 17 - 26
RHEUMATOLOGY (OXFORD, 12 October 2017 (2017-10-12)
See also references of EP 3960762A4
ANNU REV IMMUNOL., vol. 14, 1996, pages 97 - 440
INFLAMM BOWEL DIS., vol. 5, no. 2, 1999, pages 19 - 33
RHEUMATOLOGY (OXFORD, vol. 46, no. 7, 2007, pages 1153 - 6
ANN RHEUM DIS., vol. 65, no. 6, 2006, pages 746 - 52
JEXPMED, vol. 183, no. 6, 1996, pages 2593 - 603
J INVEST DERMATOL., vol. 131, no. 3, 2011, pages 677 - 87
NENGL J MED, vol. 361, no. 9, 2009, pages 888 - 98
J INVEST DERMATOL, vol. 133, no. 1, 2013, pages 17 - 26
RHEUMATOLOGY (OXFORD, 12 October 2017 (2017-10-12)
See also references of EP 3960762A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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