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Title:
BISPECIFIC ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2024/043227
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel drug for preventing cancer, suppressing the progression of a symptom of cancer, suppressing the recurrence of cancer, or treating cancer.　As the results of intensive studies, the present inventors focused attention on Allergin-1 that is a target molecule involved in the regulation of cancer immunity, and found a bispecific antibody capable of binding specifically respectively to two different epitopes on the S1 and S2 domains, said domains being the extracellular domains of Allergin-1, as a substance that can solve this problem. The present inventors confirmed that this antibody is useful for preventing cancer, suppressing the progression of a symptom of cancer, suppressing the recurrence of cancer, or treating cancer.

Inventors:
SAITO AKINA (JP)
SHIBAYAMA SHIRO (JP)
ARIMA HIROSHI (JP)
NAKAMURA MASATOSHI (JP)
GUNDE TEA (CH)
HESS CHRISTIAN (CH)
SIMONIN ALEXANDRE (CH)
WARMUTH STEFAN (CH)
JOHANSSON MARIA (CH)
BROCK MATTHIAS (CH)
WEINERT CHRISTOPHER (CH)
SPIGA FABIO MARIO (CH)
Application Number:
PCT/JP2023/030111
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C07K16/46; C12N15/13
Domestic Patent References:
WO2017038997A12017-03-09
WO2019016784A12019-01-24
Foreign References:
US20220073635A12022-03-10
CN116411070A2023-07-11
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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