Title:
BLASTOCYSTIS BILAMINARIS MODEL AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2022/114188
Kind Code:
A1
Abstract:
A method for producing a mammalian blastocystis bilaminaris model, comprising a step for forming a cell mass containing a hypoblast-like cell derived from a naive mammalian pluripotent stem cell and a mammalian pluripotent stem cell corresponding to an epiblast-like cell.
Inventors:
TAKASHIMA YASUHIRO (JP)
OKUBO TAKUMI (JP)
OKUBO TAKUMI (JP)
Application Number:
PCT/JP2021/043655
Publication Date:
June 02, 2022
Filing Date:
November 29, 2021
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/073; C12N5/0735; C12N5/10
Domestic Patent References:
| WO2019093340A1 | 2019-05-16 | |||
| WO2021106765A1 | 2021-06-03 |
Foreign References:
| JP2016518831A | 2016-06-30 | |||
| JP2016521971A | 2016-07-28 | |||
| JP2016508365A | 2016-03-22 |
Other References:
MA HUAIXIAO, ZHAI JINGLEI, WAN HAIFENG, JIANG XIANGXIANG, WANG XIAOXIAO, WANG LIN, XIANG YUNLONG, HE XIECHAO, ZHAO ZHEN-AO, ZHAO B: "In vitro culture of cynomolgus monkey embryos beyond early gastrulation", SCIENCE, vol. 366, no. 6467, 15 November 2019 (2019-11-15), US , XP055933698, ISSN: 0036-8075, DOI: 10.1126/science.aax7890
DEGLINCERTI ALESSIA; CROFT GIST F.; PIETILA LAUREN N.; ZERNICKA-GOETZ MAGDALENA; SIGGIA ERIC D.; BRIVANLOU ALI H.: "Self-organization of the in vitro attached human embryo", NATURE, vol. 533, no. 7602, 4 May 2016 (2016-05-04), London, pages 251 - 254, XP037445781, ISSN: 0028-0836, DOI: 10.1038/nature17948
MASCETTI VICTORIA L.; PEDERSEN ROGER A.: "Contributions of Mammalian Chimeras to Pluripotent Stem Cell Research", CELL STEM CELL, vol. 19, no. 2, 10 August 2016 (2016-08-10), AMSTERDAM, NL , pages 163 - 175, XP029675887, ISSN: 1934-5909, DOI: 10.1016/j.stem.2016.07.018
MASAHITO TACHIBANA, MICHELLE SPARMAN, CATHY RAMSEY, HONG MA, HYO-SANG LEE, MARIA CECILIA T. PENEDO, SHOUKHRAT MITALIPOV: "Generation of Chimeric Rhesus Monkeys", CELL, vol. 148, no. 1-2, 1 January 2012 (2012-01-01), Amsterdam NL , pages 285 - 295, XP055459089, ISSN: 0092-8674, DOI: 10.1016/j.cell.2011.12.007
TAKASHIMA, YASUHIRO: "Induction of Pre-Implantation Human Embryo Extracorporeal Tissue Using Initialization Technology, Analysis of Early Human Embryogenesis", GRANT-IN-AID FOR SCIENTIFIC RESEARCH DATABASE; PROJECT / AREA NUMBER 15H06329, KAKEN, JP, 6 January 2017 (2017-01-06), JP, XP009537292
OKUBO, TAKUMI : "Construction of Implantation-Phase Human Embryo Model Using Pluripotent Stem Cells", EXPERIMENTAL MEDICINE, vol. 39, no. 18, 1 November 2021 (2021-11-01), JP , pages 2891 - 2976, XP009536873, ISSN: 0288-5514
DEGLINCERTI ALESSIA; CROFT GIST F.; PIETILA LAUREN N.; ZERNICKA-GOETZ MAGDALENA; SIGGIA ERIC D.; BRIVANLOU ALI H.: "Self-organization of the in vitro attached human embryo", NATURE, vol. 533, no. 7602, 4 May 2016 (2016-05-04), London, pages 251 - 254, XP037445781, ISSN: 0028-0836, DOI: 10.1038/nature17948
MASCETTI VICTORIA L.; PEDERSEN ROGER A.: "Contributions of Mammalian Chimeras to Pluripotent Stem Cell Research", CELL STEM CELL, vol. 19, no. 2, 10 August 2016 (2016-08-10), AMSTERDAM, NL , pages 163 - 175, XP029675887, ISSN: 1934-5909, DOI: 10.1016/j.stem.2016.07.018
MASAHITO TACHIBANA, MICHELLE SPARMAN, CATHY RAMSEY, HONG MA, HYO-SANG LEE, MARIA CECILIA T. PENEDO, SHOUKHRAT MITALIPOV: "Generation of Chimeric Rhesus Monkeys", CELL, vol. 148, no. 1-2, 1 January 2012 (2012-01-01), Amsterdam NL , pages 285 - 295, XP055459089, ISSN: 0092-8674, DOI: 10.1016/j.cell.2011.12.007
TAKASHIMA, YASUHIRO: "Induction of Pre-Implantation Human Embryo Extracorporeal Tissue Using Initialization Technology, Analysis of Early Human Embryogenesis", GRANT-IN-AID FOR SCIENTIFIC RESEARCH DATABASE; PROJECT / AREA NUMBER 15H06329, KAKEN, JP, 6 January 2017 (2017-01-06), JP, XP009537292
OKUBO, TAKUMI : "Construction of Implantation-Phase Human Embryo Model Using Pluripotent Stem Cells", EXPERIMENTAL MEDICINE, vol. 39, no. 18, 1 November 2021 (2021-11-01), JP , pages 2891 - 2976, XP009536873, ISSN: 0288-5514
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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