Title:
COMPOUND HAVING INHIBITORY ACTION AGAINST EXCESSIVE MITOCHONDRIAL DIVISIONS
Document Type and Number:
WIPO Patent Application WO/2022/114187
Kind Code:
A1
Abstract:
The present invention provides a compound for treating or preventing diseases caused by excessive mitochondrial divisions. The present invention relates to a compound represented by formula (1) (in the formula: R1 and R1' are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower cycloalkyl, or the like; R2 is optionally substituted lower alkyl, optionally substituted lower cycloalkyl, or the like; R3 and R4 are each independently hydrogen, halogen, hydroxy, nitro, cyano, optionally substituted lower alkyl or the like; R5 and R6 are each independently optionally substituted lower alkyl, optionally substituted lower cycloalkyl, or the like; X is nitrogen or oxygen; Y is carbon, nitrogen, or oxygen; and the broken line represents the presence or absence of a bond), a pharmaceutically acceptable salt or solvate thereof, or a prodrug thereof.
Inventors:
KAWANISHI EIJI (JP)
OJIDA AKIO (JP)
NISHIDA MOTOHIRO (JP)
KATO YURI (JP)
OJIDA AKIO (JP)
NISHIDA MOTOHIRO (JP)
KATO YURI (JP)
Application Number:
PCT/JP2021/043654
Publication Date:
June 02, 2022
Filing Date:
November 29, 2021
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61P1/04; A61K31/4418; A61K31/4422; A61K31/4745; A61P3/10; A61P9/04; A61P21/00; A61P43/00; C07D211/90; C07D213/80; C07D213/82; C07D471/04
Domestic Patent References:
| WO2016080516A1 | 2016-05-26 | |||
| WO1999032446A1 | 1999-07-01 | |||
| WO2020241638A1 | 2020-12-03 |
Foreign References:
| CN107216352A | 2017-09-29 | |||
| JPS61145180A | 1986-07-02 | |||
| JPH0578319A | 1993-03-30 | |||
| US20110118299A1 | 2011-05-19 | |||
| US4478834A | 1984-10-23 | |||
| JP4613496B2 | 2011-01-19 | |||
| JP2008044871A | 2008-02-28 | |||
| JP2004359675A | 2004-12-24 | |||
| JP2013014549A | 2013-01-24 |
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KAMETANI T, OGASAWARA K, YAMANAKA T, CADOGAN N J I G, CAMERON-WOOD R K, MACKIE R J G, SEARLE J, CHEM, SOC, CADOGAN 4831 J I G, TOD: "Nitrenes. Part III The Reaction of 4-(2-Nitrophenyl)pyridine Deriv- atives with Triethyl Phosphite", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C: ORGANIC CHEMISTRY.>6015C, CHEMICAL SOCIETY. LETCHWORTH., GB, no. 1, 1 January 1969 (1969-01-01), GB , pages 138 - 140, XP055933158, ISSN: 0022-4952
SONG, MDORN, G.W: "Mitoconfusion: Noncanonical functioning of dynamism factors in static mitochondria of the heart", CELL METAB., vol. 21, 2015, pages 195 - 205
DORN, G.W: "Mitochondrial fission/fusion and cardiomyopathy", CURR. OPIN. GENET. DEV, vol. 38, 2016, pages 38 - 44, XP029767522, DOI: 10.1016/j.gde.2016.03.001
HAGIR B SULIMANCLAUDE A PIANTADOSI: "Mitochondrial Quality Control as a Therapeutic Target", PHARMACOL REV, vol. 68, no. 1, January 2016 (2016-01-01), pages 20 - 48
PICCA AMANKOWSKI RTBURMAN JLDONISI LKIM JSMARZETTI ELEEUWENBURGH C: "Mitochondrial quality control mechanisms as molecular targets in cardiac ageing", NAT REV CARDIOL, vol. 15, no. 9, September 2018 (2018-09-01), pages 543 - 554, XP036567521, DOI: 10.1038/s41569-018-0059-z
AKIYUKI NISHIMURA 1MOTOHIRO NISHIDA, SEIKAGAKU, vol. 91, no. 4, 2019, pages 519 - 522
NISHIMURA A ET AL.: "Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial aging", SCI. SIGNAL, vol. 11, no. 556, 2018, pages eaat5185
FANDI SUTANTOMARKELLA KONSTANTINIDOUALEXANDER DOEMLING, RSC MEDICINAL CHEMISTRY, vol. 11, 2020, pages 876 - 884
KROGSGAARD-LARSEN ET AL.: "Textbook of Drug design and Discovery", April 2002, TAYLOR & FRANCIS
K. GÖRLITZER , D. BUSS: "9-Chlor-3,6-diazaphenanthrene aus Nifedipin", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 318, no. 2, 1 January 1985 (1985-01-01), Weinheim , pages 106 - 110, XP002668334, ISSN: 0365-6233, DOI: 10.1002/ardp.19853180203
KAMETANI T, YAMANAKA T, OGASAWARA K: "Nitrene. Part V.l Reaction of 4-(2-Nitrophenyl)-l,4-dihydropyridine Derivatives with Triethyl Phosphite2", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C: ORGANIC CHEMISTRY.>6015C, CHEMICAL SOCIETY. LETCHWORTH., GB, vol. 12, 1 January 1969 (1969-01-01), GB , pages 1616 - 1619, XP055933156, ISSN: 0022-4952
KAMETANI T, OGASAWARA K, YAMANAKA T, CADOGAN N J I G, CAMERON-WOOD R K, MACKIE R J G, SEARLE J, CHEM, SOC, CADOGAN 4831 J I G, TOD: "Nitrenes. Part III The Reaction of 4-(2-Nitrophenyl)pyridine Deriv- atives with Triethyl Phosphite", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C: ORGANIC CHEMISTRY.>6015C, CHEMICAL SOCIETY. LETCHWORTH., GB, no. 1, 1 January 1969 (1969-01-01), GB , pages 138 - 140, XP055933158, ISSN: 0022-4952
SONG, MDORN, G.W: "Mitoconfusion: Noncanonical functioning of dynamism factors in static mitochondria of the heart", CELL METAB., vol. 21, 2015, pages 195 - 205
DORN, G.W: "Mitochondrial fission/fusion and cardiomyopathy", CURR. OPIN. GENET. DEV, vol. 38, 2016, pages 38 - 44, XP029767522, DOI: 10.1016/j.gde.2016.03.001
HAGIR B SULIMANCLAUDE A PIANTADOSI: "Mitochondrial Quality Control as a Therapeutic Target", PHARMACOL REV, vol. 68, no. 1, January 2016 (2016-01-01), pages 20 - 48
PICCA AMANKOWSKI RTBURMAN JLDONISI LKIM JSMARZETTI ELEEUWENBURGH C: "Mitochondrial quality control mechanisms as molecular targets in cardiac ageing", NAT REV CARDIOL, vol. 15, no. 9, September 2018 (2018-09-01), pages 543 - 554, XP036567521, DOI: 10.1038/s41569-018-0059-z
AKIYUKI NISHIMURA 1MOTOHIRO NISHIDA, SEIKAGAKU, vol. 91, no. 4, 2019, pages 519 - 522
NISHIMURA A ET AL.: "Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial aging", SCI. SIGNAL, vol. 11, no. 556, 2018, pages eaat5185
FANDI SUTANTOMARKELLA KONSTANTINIDOUALEXANDER DOEMLING, RSC MEDICINAL CHEMISTRY, vol. 11, 2020, pages 876 - 884
KROGSGAARD-LARSEN ET AL.: "Textbook of Drug design and Discovery", April 2002, TAYLOR & FRANCIS
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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