Title:
BLOOD BIOMARKERS FOR NECROTIZING ENTEROCOLITIS
Document Type and Number:
WIPO Patent Application WO/2013/185134
Kind Code:
A3
Abstract:
Necrotizing Enterocolitis (NEC) biomarkers, NEC biomarker panels, and methods for obtaining a NEC signature for a sample are provided. Also provided are methods, compositions, and kits for making a Necrotizing Enterocolitis (NEC) assessment of an individual, e.g. for diagnosing NEC in a patient, prognosing NEC in a patient, treating an NEC patient, etc.. These methods find use in a number of applications, such as diagnosing and treating infants who are suspected of having NEC, intestinal perforation (IP), or sepsis.
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Inventors:
SYLVESTER KARL G (US)
TAO GUO-ZHONG (US)
TAO GUO-ZHONG (US)
Application Number:
PCT/US2013/044995
Publication Date:
February 13, 2014
Filing Date:
June 10, 2013
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
A61K38/37; C12Q1/56; C12Q1/68; G01N33/53
Domestic Patent References:
| WO2007078841A2 | 2007-07-12 |
Other References:
NG, PC ET AL.: "Host-Response Biomarkers For Diagnosis Of Late-Onset Septicemia And Necrotizing Enterocolitis In Preterm Infants.", THE JOURNAL OF CLINICAL INVESTIGATION., vol. 120, no. 8, 2010, pages 2989 - 3000
BELL, MJ ET AL.: "Neonatal Necrotizing Enterocolitis Therapeutic Decisions Based Upon Clinical Staging.", ANNALS OF SUGERY., vol. 187, no. 1, 1978, pages 1 - 7
BELL, MJ ET AL.: "Neonatal Necrotizing Enterocolitis Therapeutic Decisions Based Upon Clinical Staging.", ANNALS OF SUGERY., vol. 187, no. 1, 1978, pages 1 - 7
Attorney, Agent or Firm:
ALCAMO, Elizabeth A. (Field & Francis LLP.1900 University Avenue, Suite 20, East Palo Alto California, US)
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