Title:
BLOOD-CLOTTING-SYSTEM ANALYSIS APPARATUS AND METHOD
Document Type and Number:
WIPO Patent Application WO/2020/050417
Kind Code:
A1
Abstract:
There is provided a blood-clotting-system analysis apparatus, including: a pair of electrodes; an application unit configured to apply alternating voltage to the pair of electrodes at predetermined time intervals; a measurement unit configured to measure a complex dielectric constant of a blood sample placed between the pair of electrodes; and an analysis unit configured to analyze, by using at least two or more types of blood clotting-related assays, activity of a clotting factor and activity of a clotting inhibition factor on a basis of a complex dielectric constant of a particular frequency in a predetermined time period measured at the time intervals after an anticoagulant effect acting on the blood sample is resolved.
Inventors:
HAYASHI YOSHIHITO (JP)
LEE SEUNGMIN (JP)
FUCHIGAMI AYA (JP)
MACHIDA KENZO (JP)
LEE SEUNGMIN (JP)
FUCHIGAMI AYA (JP)
MACHIDA KENZO (JP)
Application Number:
PCT/JP2019/035270
Publication Date:
March 12, 2020
Filing Date:
September 06, 2019
Export Citation:
Assignee:
SONY CORP (JP)
International Classes:
G01N33/49; G01N27/02; G01N33/86
Domestic Patent References:
| WO2018128002A1 | 2018-07-12 | |||
| WO2016049506A1 | 2016-03-31 |
Foreign References:
| EP3133390A1 | 2017-02-22 | |||
| EP2073015A1 | 2009-06-24 | |||
| JP2010181400A | 2010-08-19 | |||
| JP2012194087A | 2012-10-11 |
Other References:
DEBNATH MAJI ET AL: "ClotChip: A Microfluidic Dielectric Sensor for Point-of-Care Assessment of Hemostasis", IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, vol. 11, no. 6, 12 September 2017 (2017-09-12), US, pages 1459 - 1469, XP055534119, ISSN: 1932-4545, DOI: 10.1109/TBCAS.2017.2739724
ISAO UCHIMURA ET AL: "Effect of circulating tissue factor on hypercoagulability in type 2 diabetes mellitus studied by rheometry and dielectric blood coagulometry", BIORHEOLOGY., vol. 53, no. 5-6, 29 March 2017 (2017-03-29), GB, pages 209 - 219, XP055661024, ISSN: 0006-355X, DOI: 10.3233/BIR-16107
YOSHIHITO HAYASHI ET AL: "Principles of Dielectric Blood Coagulometry as a Comprehensive Coagulation Test", ANALYTICAL CHEMISTRY, vol. 87, no. 19, 14 September 2015 (2015-09-14), US, pages 10072 - 10079, XP055532106, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.5b02723
Y. HAYASHI ET AL., ANALYTICAL CHEMISTRY, vol. 87, no. 19, 2015, pages 10072 - 10079
I. UCHIMURA ET AL., BIORHEOLOGY, vol. 53, 2016, pages 209 - 219
ANN CLIN BIOCHEM., vol. 54, no. 4, July 2017 (2017-07-01), pages 448 - 462
FENG ET AL., SCIENTIFIC REPORTS, vol. 4, 2014, pages 3868
ISAO UCHIMURA ET AL: "Effect of circulating tissue factor on hypercoagulability in type 2 diabetes mellitus studied by rheometry and dielectric blood coagulometry", BIORHEOLOGY., vol. 53, no. 5-6, 29 March 2017 (2017-03-29), GB, pages 209 - 219, XP055661024, ISSN: 0006-355X, DOI: 10.3233/BIR-16107
YOSHIHITO HAYASHI ET AL: "Principles of Dielectric Blood Coagulometry as a Comprehensive Coagulation Test", ANALYTICAL CHEMISTRY, vol. 87, no. 19, 14 September 2015 (2015-09-14), US, pages 10072 - 10079, XP055532106, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.5b02723
Y. HAYASHI ET AL., ANALYTICAL CHEMISTRY, vol. 87, no. 19, 2015, pages 10072 - 10079
I. UCHIMURA ET AL., BIORHEOLOGY, vol. 53, 2016, pages 209 - 219
ANN CLIN BIOCHEM., vol. 54, no. 4, July 2017 (2017-07-01), pages 448 - 462
FENG ET AL., SCIENTIFIC REPORTS, vol. 4, 2014, pages 3868
Attorney, Agent or Firm:
WATANABE Kaoru (JP)
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