Title:
BLOOD SAMPLE ANALYSIS METHOD AND SYSTEM, FOR DETERMINING DIABETES
Document Type and Number:
WIPO Patent Application WO/2017/200025
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a blood sample analysis method for determining diabetes complications in subjects with kidney damage on the basis of D- and L-amino acid content, from a blood sample; a method for examining diabetes complications; and a sample analysis system that outputs pathological information about diabetes complications. The purpose of this invention is achieved by using at least one amino acid selected from the group consisting of D-aspartic acid, D-proline, L-glutamine, and L-isoleucine, in order to determine diabetes complications.
Inventors:
ISAKA YOSHITAKA (JP)
KIMURA TOMONORI (JP)
YASUDA KEIKO (JP)
HAMASE KENJI (JP)
MITA MASASHI (JP)
KIMURA TOMONORI (JP)
YASUDA KEIKO (JP)
HAMASE KENJI (JP)
MITA MASASHI (JP)
Application Number:
PCT/JP2017/018592
Publication Date:
November 23, 2017
Filing Date:
May 17, 2017
Export Citation:
Assignee:
UNIV OSAKA (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
SHISEIDO CO LTD (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
SHISEIDO CO LTD (JP)
International Classes:
G01N33/68
Domestic Patent References:
| WO2011034088A1 | 2011-03-24 |
Foreign References:
| JP2011092100A | 2011-05-12 | |||
| JP2013224929A | 2013-10-31 |
Other References:
HIRONORI ISHIDA: "Serum D-Amino Acid Elucidated in Renal Failure", KITASATO MEDICINE, vol. 23, no. 1, 1993, pages 51 - 62, XP009512768
MEISS, E. ET AL.: "Metabolite targeting: development of a comprehensive targeted metabolomics platform for the assessment of diabetes and its complications", METABOLOMICS, vol. 12, no. 3, 9 February 2016 (2016-02-09), pages 1 - 15, XP035623424
CHEN, T. ET AL.: "820: Changes of plasma free amino acids in type 2 diabetes", DIABETOLOGIA, vol. 52, no. S1, 2009, pages S322 - S323, XP009514424, DOI: 10.1007/s00125-009-1445-1
MENDEZ, J.A. ET AL.: "Age-related reference values for plasma amino acids in a Spanish population measureed by gas chromatography-mass spectrometry", JOURNAL OF PEDIATRIC ENDOCRINOLOGY AND METABOLISM, vol. 26, no. 3-4, 1 April 2013 (2013-04-01), XP055442121
See also references of EP 3460478A4
MEISS, E. ET AL.: "Metabolite targeting: development of a comprehensive targeted metabolomics platform for the assessment of diabetes and its complications", METABOLOMICS, vol. 12, no. 3, 9 February 2016 (2016-02-09), pages 1 - 15, XP035623424
CHEN, T. ET AL.: "820: Changes of plasma free amino acids in type 2 diabetes", DIABETOLOGIA, vol. 52, no. S1, 2009, pages S322 - S323, XP009514424, DOI: 10.1007/s00125-009-1445-1
MENDEZ, J.A. ET AL.: "Age-related reference values for plasma amino acids in a Spanish population measureed by gas chromatography-mass spectrometry", JOURNAL OF PEDIATRIC ENDOCRINOLOGY AND METABOLISM, vol. 26, no. 3-4, 1 April 2013 (2013-04-01), XP055442121
See also references of EP 3460478A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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