Title:
BMP-9 COMPOSITIONS AND METHODS FOR INDUCING DIFFERENTIATION OF CHOLINERGIC NEURONS
Document Type and Number:
WIPO Patent Application WO2001017547
Kind Code:
A3
Abstract:
BMP-9 compositions and methods for their use are disclosed. The BMP-9 compositions act as a differentiating factor for the cholinergic phenotype of CNS neurons. The compositions may be used in the treatment of diseases and disorders caused by degeneration and/or malfunctioning of cholinergic neurons.
Inventors:
BLUSZTAJN JAN KRZYSZTOF
LOPEZ-COVIELLA IGNACIO
KRAUSS RAUL
THIES R SCOTT
LOPEZ-COVIELLA IGNACIO
KRAUSS RAUL
THIES R SCOTT
Application Number:
PCT/US2000/024555
Publication Date:
September 27, 2001
Filing Date:
September 07, 2000
Export Citation:
Assignee:
GENETICS INST (US)
UNIV BOSTON (US)
UNIV BOSTON (US)
International Classes:
C12N15/09; A61K38/00; A61K38/18; A61K48/00; A61P25/00; A61P25/28; (IPC1-7): A61K38/18; A61K35/30; A61P25/28; C12N5/06
Domestic Patent References:
| WO1999001159A1 | 1999-01-14 | |||
| WO1999037320A1 | 1999-07-29 | |||
| WO1995033830A1 | 1995-12-14 |
Foreign References:
| US5756457A | 1998-05-26 |
Other References:
KALYANI ANJALI ET AL: "Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 19, 1 October 1998 (1998-10-01), pages 7856 - 7868, XP002161574, ISSN: 0270-6474
LOPEZ-COVIELLA I ET AL: "Bone morphogenetic protein-9 modulates acetylcholine content and choline acetyltransferase and vesicular acetylcholine transporter gene expression in the SN56 murine septal cell line.", JOURNAL OF PHYSIOLOGY PARIS, vol. 92, no. 5-6, October 1998 (1998-10-01), Xth International Symposium on Cholinergic Mechanisms, Part III;Paris, France; 1998, pages 460 - 461, XP000982562, ISSN: 0928-4257
LOPEZ-COVIELLA IGNACIO ET AL: "Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.", SCIENCE (WASHINGTON D C), vol. 289, no. 5477, 2000, pages 313 - 316, XP002161575, ISSN: 0036-8075
LOPEZ-COVIELLA I ET AL: "Bone morphogenetic proteins (BMPs) as cholinergic differentiating factors for basal forebrain neurons.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 25, no. 1-2, 1999, 29th Annual Meeting of the Society for Neuroscience, Part 1;Miami Beach, Florida, USA; October 23-28, 1999, pages 517, XP000982558, ISSN: 0190-5295
LOPEZ-COVIELLA I ET AL: "Bone morphogenetic protein-9 modulates acetylcholine content and choline acetyltransferase and vesicular acetylcholine transporter gene expression in the SN56 murine septal cell line.", JOURNAL OF PHYSIOLOGY PARIS, vol. 92, no. 5-6, October 1998 (1998-10-01), Xth International Symposium on Cholinergic Mechanisms, Part III;Paris, France; 1998, pages 460 - 461, XP000982562, ISSN: 0928-4257
LOPEZ-COVIELLA IGNACIO ET AL: "Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.", SCIENCE (WASHINGTON D C), vol. 289, no. 5477, 2000, pages 313 - 316, XP002161575, ISSN: 0036-8075
LOPEZ-COVIELLA I ET AL: "Bone morphogenetic proteins (BMPs) as cholinergic differentiating factors for basal forebrain neurons.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 25, no. 1-2, 1999, 29th Annual Meeting of the Society for Neuroscience, Part 1;Miami Beach, Florida, USA; October 23-28, 1999, pages 517, XP000982558, ISSN: 0190-5295
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