Title:
BODIPY COMPOUND, AND TEMPERATURE-SENSITIVE FLUORESCENT SENSOR OF CELL ORGANELLES COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/229338
Kind Code:
A1
Abstract:
The present invention relates to a BODIPY compound, and a temperature-sensitive fluorescent sensor of cell organelles comprising same. A BODIPY compound according to one aspect can quickly detect minute temperature changes with high sensitivity and accurately target various cell organelles, and has no cytotoxicity. That is, the BODIPY compound according to one aspect can visualize the temperature for each cell organelle and is expected to be useful as a temperature-sensitive fluorescent sensor of cell organelles.
Inventors:
CHANG YOUNG-TAE (KR)
LIU XIAO (KR)
SATOSHI ARAI (JP)
TAKERU YAMAZAKI (JP)
LIU XIAO (KR)
SATOSHI ARAI (JP)
TAKERU YAMAZAKI (JP)
Application Number:
PCT/KR2023/006990
Publication Date:
November 30, 2023
Filing Date:
May 23, 2023
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
POSTECH ACAD IND FOUND (KR)
NATIONAL UNIV CORPORATION KANAZAWA (JP)
POSTECH ACAD IND FOUND (KR)
NATIONAL UNIV CORPORATION KANAZAWA (JP)
International Classes:
C07F5/02; G01K11/16; G01K11/20
Foreign References:
| JP2015218304A | 2015-12-07 |
Other References:
DATABASE Registry 4 March 2021 (2021-03-04), ANONYMOUS: "INDEX NAME NOT YET ASSIGNED", XP093112216, retrieved from STNext Database accession no. 2602662-20-2
TSUJI GENICHIRO, HATTORI TAKAYUKI, KATO MASASHI, HAKAMATA WATARU, INOUE HIDESHI, NAITO MIKIHIKO, KURIHARA MASAAKI, DEMIZU YOSUKE, : "Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 20, 1 November 2018 (2018-11-01), AMSTERDAM, NL, pages 5494 - 5498, XP093112210, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.09.028
YUANJI XIAO, XINQIAN YANG, XINJIAN CHENG, SHUANGYU XIONG AND RONG CHEN: "Fluorescent macromolecular chemosensors for highly and selectively detecting of 2, 4, 6-trinitrophenol", MATERIALS RESEARCH EXPRESS, IOP PUBLISHING, GB, vol. 7, no. 10, 1 October 2020 (2020-10-01), GB , pages 105304 - 14, XP009550872, ISSN: 2053-1591, DOI: 10.1088/2053-1591/abbbab
RAMKUMAR KAVYA, SAMANTA SOMA, KYANI ANAHITA, YANG SUHUI, TAMURA SHUZO, ZIEMKE ELIZABETH, STUCKEY JEANNE A., LI SI, CHINNASWAMY KRI: "Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 7, no. 1, 5 October 2016 (2016-10-05), UK, pages 13084, XP093112214, ISSN: 2041-1723, DOI: 10.1038/ncomms13084
TSUJI GENICHIRO, HATTORI TAKAYUKI, KATO MASASHI, HAKAMATA WATARU, INOUE HIDESHI, NAITO MIKIHIKO, KURIHARA MASAAKI, DEMIZU YOSUKE, : "Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 20, 1 November 2018 (2018-11-01), AMSTERDAM, NL, pages 5494 - 5498, XP093112210, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.09.028
YUANJI XIAO, XINQIAN YANG, XINJIAN CHENG, SHUANGYU XIONG AND RONG CHEN: "Fluorescent macromolecular chemosensors for highly and selectively detecting of 2, 4, 6-trinitrophenol", MATERIALS RESEARCH EXPRESS, IOP PUBLISHING, GB, vol. 7, no. 10, 1 October 2020 (2020-10-01), GB , pages 105304 - 14, XP009550872, ISSN: 2053-1591, DOI: 10.1088/2053-1591/abbbab
RAMKUMAR KAVYA, SAMANTA SOMA, KYANI ANAHITA, YANG SUHUI, TAMURA SHUZO, ZIEMKE ELIZABETH, STUCKEY JEANNE A., LI SI, CHINNASWAMY KRI: "Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 7, no. 1, 5 October 2016 (2016-10-05), UK, pages 13084, XP093112214, ISSN: 2041-1723, DOI: 10.1038/ncomms13084
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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