Title:
BORON-CONTAINING COMPOUNDS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/213358
Kind Code:
A1
Abstract:
Provided in the present invention are boron-containing compounds as represented by formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions including same, and an application of serving as a selective estrogen receptor degrader (SERD) in the prevention or treatment of a related illness.
Inventors:
GU PENG (CN)
LIU LEI (CN)
ZHANG GUOBAO (CN)
ZHOU FENG (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
LIU LEI (CN)
ZHANG GUOBAO (CN)
ZHOU FENG (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2021/088291
Publication Date:
October 28, 2021
Filing Date:
April 20, 2021
Export Citation:
Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
C07F5/04; A61K31/437; A61K31/4375; A61K31/472; A61K31/4725; A61K31/69; A61P15/00; A61P35/00; C07D401/04; C07D401/12; C07D401/14; C07D471/04
Domestic Patent References:
| WO2018102261A2 | 2018-06-07 | |||
| WO2019228443A1 | 2019-12-05 |
Foreign References:
| CN109219604A | 2019-01-15 | |||
| CN107108611A | 2017-08-29 | |||
| CN109415388A | 2019-03-01 |
Other References:
LIU JIAWANG, ZHENG SHILONG, GUO SHANCHUN, ZHANG CHANGDE, ZHONG QIU, ZHANG QIANG, MA PENG, SKRIPNIKOVA ELENA V., BRATTON MELYSSA R.: "Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 1, 12 January 2017 (2017-01-12), US , pages 102 - 106, XP055860947, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.6b00410
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