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Title:
BORON-CONTAINING DIACYLHYDRAZINES
Document Type and Number:
WIPO Patent Application WO/2014/144380
Kind Code:
A8
Abstract:
The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

Inventors:
CHELLAPPAN SHEELA K (US)
HORMANN ROBERT E (US)
SHULMAN INNA (US)
Application Number:
PCT/US2014/028768
Publication Date:
August 13, 2015
Filing Date:
March 14, 2014
Export Citation:
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Assignee:
INTREXON CORP (US)
International Classes:
C07C243/38
Attorney, Agent or Firm:
ESMOND, Robert, W. et al. (Kessler Goldstein & Fox, P.L.L.C.,1100 New York Avenue, N.W, Washington DC, US)
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