Title:
BORON NEUTRON CAPTURE TREATINGSYSTEM AND APPLICATION OF Α-AMINO ACID-LIKE BORON TRIFLUORIDE INMANUFACTURING MEDICAMENT FOR TREATING TUMORS
Document Type and Number:
WIPO Patent Application WO/2017/162093
Kind Code:
A1
Abstract:
As one aspect of the present invention, disclosed is a boron neutron capture therapy system, comprising: a boron neutron capture therapy device and an α-amino acid-like boron trifluoride; the α-amino acid-like boron trifluoride has a structure as shown in the formula (I) wherein R refers to hydrogen, methyl, isopropyl,1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzylor hydroxybenzyl, and M refers to H or a metal atom; theenergy generated after a neutron beam generated by the boron neutron capture therapy device acts on the α-amino acid-like boron trifluoride can damage DNA of tumour cells. As another aspect of the present invention, disclosed also is the application of an α-amino acid-like boron trifluoride in manufacturing medicament for treating tumors.
Inventors:
WANG ZHENG (CN)
LI SHIHONG (CN)
LUO ZHIGANG (CN)
LIU YUANHAO (CN)
LI SHIHONG (CN)
LUO ZHIGANG (CN)
LIU YUANHAO (CN)
Application Number:
PCT/CN2017/076946
Publication Date:
September 28, 2017
Filing Date:
March 16, 2017
Export Citation:
Assignee:
NEUBORON MEDTECH LTD (CN)
International Classes:
A61N5/10
Domestic Patent References:
| WO2015156385A1 | 2015-10-15 |
Foreign References:
| US20130225861A1 | 2013-08-29 | |||
| CN104548388A | 2015-04-29 | |||
| CN1154073A | 1997-07-09 | |||
| JP5383237B2 | 2014-01-08 |
Other References:
ZHOU, YONGMAO: "T he Boron Neutron Capture Therapy (BNCT) Status to Go into the New Era", ENGINEERING SCIENCE, 5 December 2012 (2012-12-05), XP009510135
See also references of EP 3424561A4
See also references of EP 3424561A4
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