BRADYKININ ANTAGONISTS

WIPO Patent Application WO1999064039

A9

Disclosed are multibinding compounds which are bradykinin antagonists. The multibinding compounds of this invention contain from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a bradykinin antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as cancer, pain, shock, asthma, rhinitis, arthritis, inflammatory bowel disease, and the like.

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CHRISTENSEN BURTON G (US)
NATARAJAN MAYA (US)
GRIFFIN JOHN H (US)

PCT/US1999/012674

October 12, 2000

June 07, 1999

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ADVANCED MEDICINE INC (US)
CHRISTENSEN BURTON G (US)
NATARAJAN MAYA (US)
GRIFFIN JOHN H (US)

G01N33/53; A61K31/00; A61K31/4184; A61K31/437; A61K31/4439; A61K31/444; A61K31/47; A61K31/4709; A61K31/496; A61K31/498; A61K38/00; A61K39/00; A61K39/395; A61K39/44; A61K51/00; A61P1/04; A61P9/02; A61P11/06; A61P19/02; A61P25/04; A61P27/16; A61P35/00; A61P43/00; C07D211/90; C07D215/24; C07D235/26; C07D241/42; C07D471/04; C07K2/00; C07K4/00; G01N33/543; G01N33/566; (IPC1-7): A61K38/00; A61K39/00; A61K39/44; A61K39/395; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566

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