BRAIN GLIOMA BIOMARKER MLKL GENE AND USE THEREOF

Title:

BRAIN GLIOMA BIOMARKER MLKL GENE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/147790

Kind Code:

A1

Abstract:

Disclosed in the present invention are a brain glioma biomarker MLKL gene and a use thereof. MLKL expression is remarkably high in brain glioma; the high-expression MLKL gene and protein are related to poor prognosis of glioma; reducing MLKL expression can obviously inhibit the growth of malignant glioma cells; therefore the MLKL gene and the expression product thereof can be used as molecular markers for prognosis evaluation and treatment effects; and MLKL can also be used as a target for treating glioma. The present invention also discloses a detection kit for brain glioma diagnosis, screening and/or prognosis, a siRNA nucleic acid-lipid particle, a MLKL gene expression inhibitor siRNA, a GalNAc-siRNA conjugate, and uses thereof in brain glioma diagnosis, screening and/or prognosis detection.

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Inventors:

LI JIXI (CN)
GAO WENQING (CN)
LI YUANYUAN (CN)

Application Number:

PCT/CN2023/085516

Publication Date:

August 10, 2023

Filing Date:

March 31, 2023

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Assignee:

UNIV FUDAN (CN)

International Classes:

A61K45/00; C12Q1/68; A61P35/00

Domestic Patent References:

WO2008031165A1	2008-03-20
WO2009106065A2	2009-09-03
WO2010022444A1	2010-03-04
WO2010122135A2	2010-10-28

Foreign References:

CN114634984A	2022-06-17
CN102516384A	2012-06-27
CN111655278A	2020-09-11
CN1207774A	1999-02-10
US20210121522A1	2021-04-29

Other References:

ANDRÉ-GRÉGOIRE GWENNAN, DOUANNE TIPHAINE, THYS AN, MAGHE CLÉMENT, JACOBS KATHRYN, BALLU CYNDIE, TRILLET KILIAN, BUSNELLI IGNACIO, : "The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma", BIORXIV, vol. 2021, 14 April 2021 (2021-04-14), pages 1 - 46, XP093083791, DOI: 10.1101/2021.01.12.426398

Attorney, Agent or Firm:

WATSON & BAND INTELLECTUAL PROPERTY AGENT LTD. (CN)

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