Title:
C-FMS KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004096795
Kind Code:
A3
Abstract:
The invention is directed to compounds of formulae (I), (II) and (III), wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
Inventors:
PLAYER MARK R (US)
BAINDUR NAND (US)
BRANDT BENJAMIN M (US)
CHADHA NARESH (US)
PATCH RAYMOND J (US)
ASGARI DAVOUD (US)
GEORGIADIS TAXIARCHIS (US)
BAINDUR NAND (US)
BRANDT BENJAMIN M (US)
CHADHA NARESH (US)
PATCH RAYMOND J (US)
ASGARI DAVOUD (US)
GEORGIADIS TAXIARCHIS (US)
Application Number:
PCT/US2004/012729
Publication Date:
March 10, 2005
Filing Date:
April 26, 2004
Export Citation:
Assignee:
DIMENSIONAL PHARM INC (US)
PLAYER MARK R (US)
BAINDUR NAND (US)
BRANDT BENJAMIN M (US)
CHADHA NARESH (US)
PATCH RAYMOND J (US)
ASGARI DAVOUD (US)
GEORGIADIS TAXIARCHIS (US)
PLAYER MARK R (US)
BAINDUR NAND (US)
BRANDT BENJAMIN M (US)
CHADHA NARESH (US)
PATCH RAYMOND J (US)
ASGARI DAVOUD (US)
GEORGIADIS TAXIARCHIS (US)
International Classes:
A61K31/16; A61K31/195; A61K31/452; A61K31/4545; A61K31/55; A61P35/00; C07D207/34; C07D207/42; C07D213/81; C07D223/12; C07D231/16; C07D231/38; C07D261/18; C07D265/02; C07D265/30; C07D279/12; C07D295/14; C07D307/68; C07D307/71; C07D307/72; C07D401/12; C07D405/00; C07D405/12; C07D491/04; (IPC1-7): C07D307/72; C07D307/68; C07D261/18; C07D213/81; C07D295/14; C07D231/16; C07D405/12; C07D207/42; C07D401/12; C07D207/34; C07D491/04; A61K31/55; A61P35/00
Domestic Patent References:
| WO2003103648A1 | 2003-12-18 | |||
| WO2003103658A1 | 2003-12-18 | |||
| WO2000062778A1 | 2000-10-26 | |||
| WO1995019169A2 | 1995-07-20 |
Foreign References:
| US4172947A | 1979-10-30 | |||
| DE2635818A1 | 1977-11-17 | |||
| EP1193246A1 | 2002-04-03 |
Other References:
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002307086
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002307088
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307089
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307090
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307091
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307092
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307093
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307094
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307095
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307096
MELIK-ORGANDZHANYAN, R. G. ET AL.: "New Method for the Synthesis of Polyfunctional 5-Aminopyrimidines", CHEM. HETEROCYCL. COMPD. ENGL. TRANSL., 1983, pages 100 - 102, XP009040286
YOSHINO, H. ET AL.: "Novel Sulfonamides as Potential, Systematically Active Antitumor Agents", J. MED. CHEM., vol. 35, 1992, pages 2496 - 2497, XP002307083
HODSON, S. J. ET AL.: "Alpha1-Adrenoceptor Activation: A Comparison of 4-(Anilinomethyl)imidazoles and 4-(Phenoxymethyl)imidazoles to Related 2-Imidazolines", BIOORG. MED. CHEM. LETT., vol. 12, 2002, pages 3449 - 3452, XP002307084
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307097
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307098
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307099
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307100
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307101
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307102
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307103
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307104
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002307105, retrieved from STN
KLUNDER, J. M. ET AL.: "Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones.", J. MED. CHEM., vol. 35, 1992, pages 1887 - 1897, XP002307085
TRAXLER P: "TYROSINE KINASE INHIBITORS IN CANCER TREATMENT (PART II)", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 8, no. 12, 1998, pages 1599 - 1625, XP001183544, ISSN: 1354-3776
SHOWALTER ET AL: "Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, 1999, pages 5464 - 5474, XP002210181, ISSN: 0022-2623
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002307088
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307089
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307090
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307091
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307092
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307093
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307094
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307095
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307096
MELIK-ORGANDZHANYAN, R. G. ET AL.: "New Method for the Synthesis of Polyfunctional 5-Aminopyrimidines", CHEM. HETEROCYCL. COMPD. ENGL. TRANSL., 1983, pages 100 - 102, XP009040286
YOSHINO, H. ET AL.: "Novel Sulfonamides as Potential, Systematically Active Antitumor Agents", J. MED. CHEM., vol. 35, 1992, pages 2496 - 2497, XP002307083
HODSON, S. J. ET AL.: "Alpha1-Adrenoceptor Activation: A Comparison of 4-(Anilinomethyl)imidazoles and 4-(Phenoxymethyl)imidazoles to Related 2-Imidazolines", BIOORG. MED. CHEM. LETT., vol. 12, 2002, pages 3449 - 3452, XP002307084
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307097
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307098
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307099
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307100
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307101
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307102
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307103
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002307104
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002307105, retrieved from STN
KLUNDER, J. M. ET AL.: "Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones.", J. MED. CHEM., vol. 35, 1992, pages 1887 - 1897, XP002307085
TRAXLER P: "TYROSINE KINASE INHIBITORS IN CANCER TREATMENT (PART II)", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 8, no. 12, 1998, pages 1599 - 1625, XP001183544, ISSN: 1354-3776
SHOWALTER ET AL: "Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, 1999, pages 5464 - 5474, XP002210181, ISSN: 0022-2623
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