Title:
NOVEL INDOLE DERIVATIVES, METHOD OF PREPARING SAME IN THE FORM OF MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, KDR INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004096792
Kind Code:
A3
Abstract:
The invention relates to products having formula (I), wherein: R1 denotes pyrazolyl or indazolyl; R2 and R3 denote H, halogen, hydroxyl, nitro, cyano, R4, -OR4, -COR4, -OC(=O)R4, -C(=O)OR4, -C(=O)OH, -N(R5)C(=O)R4, -N(R5)C(=O)OR4, -S(O)nR4, -S(O)nOR4, -N(R5)SO2R4, -NY1Y2, -C(=O)NY1Y2, -N(R5)C(=O)NY1Y2, -S(O)nNY1Y2 and -OC(=O)NY1Y2; R4 denotes, for example, alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl; R5 denotes, for example, H, alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl; Y1 and Y2 denote, for example, H, alkyl, alkenyl, cycloalkyl, heterocycloalykl, aryl, arylcarboxy, heteroaryl and heteroarylcarboxy, and are optionally substituted, or Y1 and Y2 together with N form an amine cycle; and n denotes 0 to 2, all of said radicals being optionally substituted. The invention relates to the use of the aforementioned products in all isomeric forms and the salts thereof as medicaments, particularly as KDR inhibitors.
Inventors:
UGOLINI ANTONIO
BOUCHARD HERVE
BOUCHARD HERVE
Application Number:
PCT/FR2004/000979
Publication Date:
September 15, 2005
Filing Date:
April 22, 2004
Export Citation:
Assignee:
AVENTIS PHARMA SA (FR)
International Classes:
A61P9/00; A61P35/00; C07D401/14; C07D403/04; C07D405/14; (IPC1-7): C07D403/04; A61K31/416; A61P7/00; A61P35/00; C07D401/14; C07D405/14
Domestic Patent References:
| WO2003024969A1 | 2003-03-27 | |||
| WO2001053268A2 | 2001-07-26 |
Foreign References:
| FR2831537A1 | 2003-05-02 |
Other References:
VLADIMIR V ROZHKOV ET AL: "Synthesis of 2-aryl- and 2-hetaryl-4,6-dinitroindoles from 2,4,6-trinitrotoluene", SYNTHESIS, GEORG THIEME VERLAG. STUTTGART, DE, vol. 12, 1999, pages 2065 - 2070, XP002187465, ISSN: 0039-7881
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