Title:
CALCIUM RECEPTOR-ACTIVE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1998/001417
Kind Code:
A1
Abstract:
Novel calcium receptor-active compounds represented by the following general formula: Ar�1?-[CR?1�R?2�]�p?-X-[CR?3�R?4�]�q?-[CR?5�R?6�]-NR?7�-[CR?8�R?9�]-Ar�2? wherein Ar�1? is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroaryl-methyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7�, R?8� and R?9� represent, for example, each hydrogen or alkyl; Ar�2? is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6; and q is an integer of from 0 to 14.
Inventors:
SAKAI TERUYUKI (JP)
TAKAMI ATSUYA (JP)
SUZUKI RIKA (JP)
TAKAMI ATSUYA (JP)
SUZUKI RIKA (JP)
Application Number:
PCT/JP1997/002358
Publication Date:
January 15, 1998
Filing Date:
July 08, 1997
Export Citation:
Assignee:
KIRIN BREWERY (JP)
NPS PHARMA INC (US)
SAKAI TERUYUKI (JP)
TAKAMI ATSUYA (JP)
SUZUKI RIKA (JP)
NPS PHARMA INC (US)
SAKAI TERUYUKI (JP)
TAKAMI ATSUYA (JP)
SUZUKI RIKA (JP)
International Classes:
A61K31/165; A61K31/4035; A61P5/20; C07C211/30; C07C217/20; C07C217/58; C07C237/06; C07C237/08; C07C237/10; C07C317/18; C07C317/28; C07C323/25; C07D207/335; C07D209/08; C07D209/14; C07D209/44; C07D209/88; C07D213/38; C07D213/40; C07D213/70; C07D215/36; C07D241/12; C07D263/58; C07D277/28; C07D277/74; C07D281/06; C07D307/52; C07D307/91; C07D311/30; C07D317/58; C07D333/20; C07D333/34; C07D207/32; (IPC1-7): C07C211/30; C07C211/29; C07C211/27; C07C217/14; C07C225/16; C07C237/04; C07C323/23; C07C317/26; C07D209/08; C07D209/12; C07D209/14; C07D307/91; C07D263/58; C07D311/30; C07D215/36; C07D277/70; C07D281/10; A61K31/40; A61K31/42; A61K31/35; A61K31/34; A61K31/47
Domestic Patent References:
| WO1994018959A1 | 1994-09-01 | |||
| WO1996012697A2 | 1996-05-02 | |||
| WO1994018959A1 | 1994-09-01 | |||
| WO1993004373A1 | 1993-03-04 | |||
| WO1995011221A1 | 1995-04-27 | |||
| WO1996012697A2 | 1996-05-02 |
Foreign References:
| JPH06510531A | 1994-11-24 |
Other References:
HETEROCYCLES, 35(1), (1977), TAKANO et al., "A Facile Route to Tetrahydroisoquinoline Alkaloids via Sulfoxide Mediated Cyclization", p. 47-52.
J. PHARM. SCI., 65(4), (1976), RILEY et al., "Synthesis and alpha-Adrenolytic Activity of Chiral N-Aralkyl-beta-Haloethylamines", p. 544-547.
CHEMICAL ABSTRACTS, Vol. 63, (1965), (Columbus, Ohio, USA), Abstract No. 2928b, WELLCOME FOUNDATION LTD., "Quaternary Ammonium Compounds"; & GB,A,982 572.
CHEMICAL ABSTRACTS, Vol. 60, (1964), (Columbus, Ohio, USA), Abstract No. 11246g, ROBERT P. HALLIDAY et al., "Evaluation of Certain Hypotensive Agents. V. Substituted Polymethylene Diamines"; & J. PHARM. SCI., 53(1), (1964), p. 19-23.
CHEMICAL ABSTRACTS, Vol. 60, (1964), (Columbus, Ohio, USA), Abstract No. 1692c, JERRY E. ROBERTSON et al., "Hypotensives. VI. Disubstituted Alkylenediamines and Related Compounds"; & J. MED. CHEM., 6(6), 1963, p. 805-807.
CHEMICAL ABSTRACTS, Vol. 60, (1964), (Columbus, Ohio, USA), Abstract No. 4920f, L. SCHUSTERITZ et al., "Structure and Action of Piperazine and Ethylenediamine Derivatives"; & ARZNEIMITTEL-FORSCH., 9, (1959), p. 628-633.
CHEMICAL ABSTRACTS, Vol. 53, (1959), (Columbus, Ohio, USA), Abstract No. 12303e, JOSEPH L. SZABO et al., "Heterocyclic Diamines and Salts"; & US,A,2 876 236.
CHEMICAL ABSTRACTS, Vol. 53, (1959), (Columbus, Ohio, USA), Abstract No. 9251b, JOSEPH L. SZABO et al., "Aliphatic Diamines and Their Salts"; & US,A,2 868 833.
CHEMICAL ABSTRACTS, Vol. 53, (1959), (Columbus, Ohio, USA), Abstract No. 8788d, ROY S. HAUSLICK et al., "Diaralkylenediamine"; & US,A,2 770 653.
CHEMICAL ABSTRACTS, Vol. 51, (1957), (Columbus, Ohio, USA), Abstract No. 7428i, LEE C. CHENEY, "Purification of Streptomycin"; & US,A,2 767 168.
BIOSCIENCE REPORTS, vol. 10, 1990, pages 493
"Calcium-Binding Proteins in Health and Disease", 1987, ACADEMIC PRESS, INC., pages: 33 - 35
BROWN ET AL., ENDOCRINOLOGY, vol. 128, 1991, pages 3047
CHEN ET AL.: "diltiazem and its analog, TA-3090", J. BONE AND MINERAL RES., vol. 5, 1990, pages 581
ZAIDI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 167, 1990, pages 807
J. PHARM. SCI., 65(4), (1976), RILEY et al., "Synthesis and alpha-Adrenolytic Activity of Chiral N-Aralkyl-beta-Haloethylamines", p. 544-547.
CHEMICAL ABSTRACTS, Vol. 63, (1965), (Columbus, Ohio, USA), Abstract No. 2928b, WELLCOME FOUNDATION LTD., "Quaternary Ammonium Compounds"; & GB,A,982 572.
CHEMICAL ABSTRACTS, Vol. 60, (1964), (Columbus, Ohio, USA), Abstract No. 11246g, ROBERT P. HALLIDAY et al., "Evaluation of Certain Hypotensive Agents. V. Substituted Polymethylene Diamines"; & J. PHARM. SCI., 53(1), (1964), p. 19-23.
CHEMICAL ABSTRACTS, Vol. 60, (1964), (Columbus, Ohio, USA), Abstract No. 1692c, JERRY E. ROBERTSON et al., "Hypotensives. VI. Disubstituted Alkylenediamines and Related Compounds"; & J. MED. CHEM., 6(6), 1963, p. 805-807.
CHEMICAL ABSTRACTS, Vol. 60, (1964), (Columbus, Ohio, USA), Abstract No. 4920f, L. SCHUSTERITZ et al., "Structure and Action of Piperazine and Ethylenediamine Derivatives"; & ARZNEIMITTEL-FORSCH., 9, (1959), p. 628-633.
CHEMICAL ABSTRACTS, Vol. 53, (1959), (Columbus, Ohio, USA), Abstract No. 12303e, JOSEPH L. SZABO et al., "Heterocyclic Diamines and Salts"; & US,A,2 876 236.
CHEMICAL ABSTRACTS, Vol. 53, (1959), (Columbus, Ohio, USA), Abstract No. 9251b, JOSEPH L. SZABO et al., "Aliphatic Diamines and Their Salts"; & US,A,2 868 833.
CHEMICAL ABSTRACTS, Vol. 53, (1959), (Columbus, Ohio, USA), Abstract No. 8788d, ROY S. HAUSLICK et al., "Diaralkylenediamine"; & US,A,2 770 653.
CHEMICAL ABSTRACTS, Vol. 51, (1957), (Columbus, Ohio, USA), Abstract No. 7428i, LEE C. CHENEY, "Purification of Streptomycin"; & US,A,2 767 168.
BIOSCIENCE REPORTS, vol. 10, 1990, pages 493
"Calcium-Binding Proteins in Health and Disease", 1987, ACADEMIC PRESS, INC., pages: 33 - 35
BROWN ET AL., ENDOCRINOLOGY, vol. 128, 1991, pages 3047
CHEN ET AL.: "diltiazem and its analog, TA-3090", J. BONE AND MINERAL RES., vol. 5, 1990, pages 581
ZAIDI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 167, 1990, pages 807
Attorney, Agent or Firm:
Yuasa, Kyozo (New Ohtemachi Building Section 206, 2-1,
Ohtemachi 2-chom, Chiyoda-ku Tokyo 100, JP)
Shamoto, Ichio (New Ohtemachi Building Section 206, 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 100, JP)
Shamoto, Ichio (New Ohtemachi Building Section 206, 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 100, JP)
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