Title:
CANCER TREATMENT METHOD
Document Type and Number:
WIPO Patent Application WO2006026313
Kind Code:
A3
Abstract:
The present invention relates to a method of treating cancer in a mammal by administration of 4-quinazolinamines and at least one additional EGFR and/or erbB-2 inhibitor. In particular, the method relates to methods of treating cancers by administration of N-{3-chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2-(methanesulphonyl) ethyl]amino} methyl)-2-furyl]-4-quinazolinamine and salts and solvates thereof in combination with at least one additional EGFR and/or erbB-2 inhibitor.
Inventors:
RUSNAK DAVID (US)
Application Number:
PCT/US2005/030148
Publication Date:
August 24, 2006
Filing Date:
August 25, 2005
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORK LTD (IE)
RUSNAK DAVID (US)
RUSNAK DAVID (US)
International Classes:
A61K31/535; C07D471/00; C07D487/00
Domestic Patent References:
| WO2002002552A1 | 2002-01-10 |
Other References:
BURRIS H.A.: "Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor Lapatinib", THE ONCOLOGIST, vol. 9, no. SUPPL. 3, June 2004 (2004-06-01), pages 10 - 15, XP002991589
CIARDIELLO F. AND TORTORA G.: "Anti-epidermal growth factor receptor drugs in cancer therapy", EXPERT OPINION INVEST DRUGS, vol. 11, no. 6, 2002, pages 755 - 768, XP009014333
WOOD E. ET AL.: "A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships...", CANCER RESEARCH, vol. 64, 15 September 2004 (2004-09-15), pages 6652 - 6659, XP003005593
CIARDIELLO F. AND TORTORA G.: "Anti-epidermal growth factor receptor drugs in cancer therapy", EXPERT OPINION INVEST DRUGS, vol. 11, no. 6, 2002, pages 755 - 768, XP009014333
WOOD E. ET AL.: "A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships...", CANCER RESEARCH, vol. 64, 15 September 2004 (2004-09-15), pages 6652 - 6659, XP003005593
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