Title:
CANNABINOIDS SELECTIVE FOR THE CB2 RECEPTOR
Document Type and Number:
WIPO Patent Application WO1999057107
Kind Code:
A3
Abstract:
Disclosed are novel cannabinoids which are selective for the CB2 receptor. The novel cannabinoids comprise a substituted or unsubstituted tricyclic cannabinoid core and a substituted or unsubstituted C5-C8 carbocyclic ring, five to eight-membered heterocyclic ring or a seven to ten membered bicyclic ring system fused to the monohydroxylated phenyl ring of the cannabinoid core. Also disclosed are methods of suppressing the immune system in a subject by administering to the subject a (e.g. immunosuppressive amount) effective amount of a novel cannabinoid described above.
Inventors:
MAKRIYANNIS ALEXANDROS
KHANOLKAR ATMARAM
LU DAI
KHANOLKAR ATMARAM
LU DAI
Application Number:
PCT/US1999/009806
Publication Date:
February 03, 2000
Filing Date:
May 04, 1999
Export Citation:
Assignee:
UNIV CONNECTICUT (US)
International Classes:
C07D311/78; (IPC1-7): C07D311/80; C07D311/92; A61K31/35
Foreign References:
| EP0276732A2 | 1988-08-03 | |||
| FR2735774A1 | 1996-12-27 |
Other References:
C. G. PITT ET AL., JOURNAL OF LABELLED COMPOUNDS, vol. 11, no. 4, 1975, pages 551 - 75, XP002123229
J. W. HUFFMAN ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, no. 12, 1998, pages 2281 - 8, XP002123230
J. W. HUFFMAN ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, no. 12, 1998, pages 2281 - 8, XP002123230
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