Title:
CONDENSED IMIDAZOLE DERIVATIVE AND THERAPEUTIC AGENT FOR LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/1999/057103
Kind Code:
A1
Abstract:
A condensed imidazole derivative represented by formula (1) or (2) wherein X and Z represent N or CH, A represents N or C-R?5¿, Y represents O, S, SO, SO¿2? or NH, k is 0 or 1, m is 0, 1 or 2 and n is 1 or 2; R?1¿ represents a phenyl group, a pyridyl group, a dihydropyridyl-4-on group or the like; R?2¿ and R?4¿ represent a phenyl group, a pyridyl group, a substituted phenyl group or the like; and R?5¿ and R?6¿ both represent H or together represent an atom group forming an aromatic ring together with the carbon atoms to which they are attached, or a pharmaceutically acceptable salt thereof, which is useful as a therapeutic agent for liver disease with no serious adverse effect.
Inventors:
NAGASAWA MASAAKI (JP)
NISHIOKA HIROYASU (JP)
SUZUKI TAKANORI (JP)
SEGAWA YOSHIHIDE (JP)
TSUZUIKE NAOKI (JP)
NISHIOKA HIROYASU (JP)
SUZUKI TAKANORI (JP)
SEGAWA YOSHIHIDE (JP)
TSUZUIKE NAOKI (JP)
Application Number:
PCT/JP1999/002309
Publication Date:
November 11, 1999
Filing Date:
April 30, 1999
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
ZERIA PHARM CO LTD (JP)
NAGASAWA MASAAKI (JP)
NISHIOKA HIROYASU (JP)
SUZUKI TAKANORI (JP)
SEGAWA YOSHIHIDE (JP)
TSUZUIKE NAOKI (JP)
ZERIA PHARM CO LTD (JP)
NAGASAWA MASAAKI (JP)
NISHIOKA HIROYASU (JP)
SUZUKI TAKANORI (JP)
SEGAWA YOSHIHIDE (JP)
TSUZUIKE NAOKI (JP)
International Classes:
C07D235/26; C07D401/04; C07D401/06; C07D401/12; C07D471/04; C07D473/00; (IPC1-7): C07D235/26; A61K31/415; A61K31/435; A61K31/44; C07D401/04; C07D401/06; C07D401/12; C07D471/04; C07D473/00
Domestic Patent References:
| WO1996038421A1 | 1996-12-05 |
Foreign References:
| JPH04208223A | 1992-07-29 |
Other References:
Chemical Abstracts Service (C A S); 1 January 1900 (1900-01-01), XP002921811, Database accession no. 84-164678
KHAN M. A., ET AL.: "SYNTHESES OF HETEROCYCLIC COMPOUNDS. PART II. N-ARYLAZOLES BY ULLMANN CONDENSATION.", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS., CHEMICAL SOCIETY. LETCHWORTH., GB, no. 01., 1 January 1970 (1970-01-01), GB, pages 85 - 91., XP002921812, ISSN: 0022-4936
KHAN M. A., ET AL.: "SYNTHESES OF HETEROCYCLIC COMPOUNDS. PART II. N-ARYLAZOLES BY ULLMANN CONDENSATION.", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS., CHEMICAL SOCIETY. LETCHWORTH., GB, no. 01., 1 January 1970 (1970-01-01), GB, pages 85 - 91., XP002921812, ISSN: 0022-4936
Attorney, Agent or Firm:
Yanagawa, Yasuo (8th floor 2-14, Yotsuya Shinjuku-ku Tokyo, JP)
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