Title:
CAPSAICIN-DERIVED PHOTOSENSITIZER, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/245857
Kind Code:
A1
Abstract:
Disclosed in the present invention are a capsaicin-derived photosensitizer, and a preparation method therefor and the use thereof. In the photosensitizer, bodipy is used as a mother nucleus, the maximum absorption peak of bodipy red-shifts to a near-infrared region by means of expanding a π system, and a capsaicin targeting group is introduced into the structure of bodipy, constructing capsaicin-derived photosensitizer cap-BDP, which has an ability to efficiently target a TRPV1 protein. Singlet oxygen, which is produced by the photosensitizer prepared in the present invention under low-power LED illumination, can target and activate a TRPV1 protein channel, causing significant calcium ion influx and inducing the apoptosis of tumor cells, and the produced singlet oxygen can directly oxidize endogenous substances (such as proteins, fatty acids or nucleic acids) of cells to cause cell apoptosis, finally achieving photo-induced difunctional synergistic treatment. In addition, the present invention uses an amphiphilic block polymer as a drug carrier to be assembled with the photosensitizer cap-BDP in a water system to form nano photosensitizer cap-BDP-NPs, which can be used for the photo-induced treatment of triple negative breast cancer.
Inventors:
GUO ZHENGQING (CN)
HE HUI (CN)
XU HAN (CN)
HUANG YANGYANG (CN)
JI DANDAN (CN)
WANG GUANGLIN (CN)
BAO KEWANG (CN)
CUI GUOQING (CN)
HE HUI (CN)
XU HAN (CN)
HUANG YANGYANG (CN)
JI DANDAN (CN)
WANG GUANGLIN (CN)
BAO KEWANG (CN)
CUI GUOQING (CN)
Application Number:
PCT/CN2022/114483
Publication Date:
December 28, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07F5/02; A61K9/14; A61K41/00; A61K47/32; A61K47/34; A61P35/00; C08G83/00; C09K11/06
Foreign References:
| CN111135298A | 2020-05-12 | |||
| CN109078185A | 2018-12-25 | |||
| CN113845551A | 2021-12-28 |
Other References:
ZHANG, YUANDONG ET AL.: "Heavy atom substituted near-infrared BODIPY nanoparticles for photodynamic therapy", DYES AND PIGMENTS, vol. 178, 10 March 2020 (2020-03-10), XP086124120, DOI: 10.1016/j.dyepig.2020.108348
ZHANG, YUANDONG ET AL.: "Hierarchical nano-to-molecular disassembly of boron dipyrromethene nanoparticles for enhanced tumor penetration and activatable photodynamic therapy", BIOMATERIALS, vol. 275, 4 June 2021 (2021-06-04), XP086707383, DOI: 10.1016/j.biomaterials.2021.120945
ZHANG, YUANDONG ET AL.: "Hierarchical nano-to-molecular disassembly of boron dipyrromethene nanoparticles for enhanced tumor penetration and activatable photodynamic therapy", BIOMATERIALS, vol. 275, 4 June 2021 (2021-06-04), XP086707383, DOI: 10.1016/j.biomaterials.2021.120945
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
Download PDF: