Title:
CARBOXYLIC ACID COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/086504
Kind Code:
A1
Abstract:
Disclosed is an excellent inhibitor of URAT1 activity, which is effective for the treatment of a disease associated with uric acid such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty nephropathy, urinary calculus, renal dysfunction, coronary artery disease and ischemic heart disease or the like. The inhibitor comprises a compound represented by the general formula [1] or a pharmaceutically acceptable salt or solvate thereof as an active ingredient. [1] wherein each symbol is as defined in the description.
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Inventors:
INOUE TERUHIKO (JP)
KIGUCHI TOSHIHIRO (JP)
HIRATA KAZUYUKI (JP)
SHINAGAWA YUKO (JP)
OGAWA NAOKI (JP)
DEAI KATSUYA (JP)
KIGUCHI TOSHIHIRO (JP)
HIRATA KAZUYUKI (JP)
SHINAGAWA YUKO (JP)
OGAWA NAOKI (JP)
DEAI KATSUYA (JP)
Application Number:
PCT/JP2007/051260
Publication Date:
August 02, 2007
Filing Date:
January 26, 2007
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
INOUE TERUHIKO (JP)
KIGUCHI TOSHIHIRO (JP)
HIRATA KAZUYUKI (JP)
SHINAGAWA YUKO (JP)
OGAWA NAOKI (JP)
DEAI KATSUYA (JP)
INOUE TERUHIKO (JP)
KIGUCHI TOSHIHIRO (JP)
HIRATA KAZUYUKI (JP)
SHINAGAWA YUKO (JP)
OGAWA NAOKI (JP)
DEAI KATSUYA (JP)
International Classes:
A61K31/538; A61K31/5415; A61P9/10; A61P13/02; A61P13/04; A61P19/02; A61P19/06; A61P43/00; C07D265/34; C07D265/36; C07D279/16
Domestic Patent References:
| WO2005011611A2 | 2005-02-10 |
Foreign References:
| JPS60166674A | 1985-08-29 | |||
| JP2000500134A | 2000-01-11 | |||
| JPH04178375A | 1992-06-25 | |||
| JPH03135917A | 1991-06-10 | |||
| JPS63107970A | 1988-05-12 | |||
| JPH1192476A | 1999-04-06 |
Other References:
TAWADA H. ET AL: "Studies on Antidiabetic Agents. IX. A New Aldose Reductase Inhibitor, AD-5467, and Related 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives: Synthesis and Biological Activity", CHEM. PHARM. BULL., vol. 38, no. 5, May 1990 (1990-05-01), pages 1238 - 1245, XP008083464
MATSUMOTO Y. ET AL: "Novel Potassium Channel Activators: Synthesis and Structure-Activity Relationship Studies of 3,4-Dihydro-2H-1,4-benzoxazine Derivatives", CHEM. PHAR. BULL., vol. 44, no. 1, January 1996 (1996-01-01), pages 103 - 114, XP008083465
CALIENDO G. ET AL: "Synthesis and Vasorelaxant Activity of New 1,4-benzoxazine Derivatives Potassium Channel Openers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 8, 2002, pages 2663 - 2669, XP003016071
KATEKAR G.F.: "[1,4]Thiazino[2,3,4-ij]quinoline Derivatives and Related Heterocycles", AUST. J. CHEM., vol. 25, 1972, pages 1283 - 1291, XP003024513
MARFAT A. AND CARTA M.P.: "An Improved Alkylation of 2H-1,4-Benzothiazin-3(4H)-one and Related Heterocyclic Anilides", SYNTHESIS, no. 5, May 1987 (1987-05-01), pages 515 - 517, XP001026331
MATSUMOTO Y. ET AL: "Novel Potassium Channel Activators: Synthesis and Structure-Activity Relationship Studies of 3,4-Dihydro-2H-1,4-benzoxazine Derivatives", CHEM. PHAR. BULL., vol. 44, no. 1, January 1996 (1996-01-01), pages 103 - 114, XP008083465
CALIENDO G. ET AL: "Synthesis and Vasorelaxant Activity of New 1,4-benzoxazine Derivatives Potassium Channel Openers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 8, 2002, pages 2663 - 2669, XP003016071
KATEKAR G.F.: "[1,4]Thiazino[2,3,4-ij]quinoline Derivatives and Related Heterocycles", AUST. J. CHEM., vol. 25, 1972, pages 1283 - 1291, XP003024513
MARFAT A. AND CARTA M.P.: "An Improved Alkylation of 2H-1,4-Benzothiazin-3(4H)-one and Related Heterocyclic Anilides", SYNTHESIS, no. 5, May 1987 (1987-05-01), pages 515 - 517, XP001026331
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, JP)
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