Title:
CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
Document Type and Number:
WIPO Patent Application WO1999047497
Kind Code:
A3
Abstract:
Compounds of formula (I), as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.
Inventors:
GAREAU YVES (CA)
LABELLE MARC (CA)
JUTEAU HELENE (CA)
GALLANT MICHEL (CA)
LACHANCE NICOLAS (CA)
BELLEY MICHEL (CA)
LABELLE MARC (CA)
JUTEAU HELENE (CA)
GALLANT MICHEL (CA)
LACHANCE NICOLAS (CA)
BELLEY MICHEL (CA)
Application Number:
PCT/CA1999/000212
Publication Date:
October 28, 1999
Filing Date:
March 12, 1999
Export Citation:
Assignee:
MERCK FROSST CANADA INC (CA)
GAREAU YVES (CA)
LABELLE MARC (CA)
JUTEAU HELENE (CA)
GALLANT MICHEL (CA)
LACHANCE NICOLAS (CA)
BELLEY MICHEL (CA)
GAREAU YVES (CA)
LABELLE MARC (CA)
JUTEAU HELENE (CA)
GALLANT MICHEL (CA)
LACHANCE NICOLAS (CA)
BELLEY MICHEL (CA)
International Classes:
C07C311/29; C07D209/08; C07D209/18; C07D213/70; C07D215/18; C07D277/32; C07D307/64; C07D333/34; C07D333/60; C07D409/12; C07D417/14; C07D521/00; (IPC1-7): C07C57/42; C07C59/68; C07C59/84; C07C311/51; C07D209/10; C07D307/64; C07D307/79
Domestic Patent References:
| WO1997025328A1 | 1997-07-17 | |||
| WO1997010246A1 | 1997-03-20 | |||
| WO1996031505A1 | 1996-10-10 | |||
| WO1996011902A1 | 1996-04-25 | |||
| WO1997008934A2 | 1997-03-13 | |||
| WO1992002495A1 | 1992-02-20 |
Foreign References:
| EP0459243A2 | 1991-12-04 | |||
| US4996214A | 1991-02-26 | |||
| EP0028063A1 | 1981-05-06 | |||
| EP0560080A1 | 1993-09-15 | |||
| EP0223593A2 | 1987-05-27 | |||
| EP0157420A2 | 1985-10-09 | |||
| EP0536713A1 | 1993-04-14 |
Other References:
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CHEMICAL ABSTRACTS, vol. 119, no. 6, 9 August 1993, Columbus, Ohio, US; abstract no. 55727y, YOKOTA, TOMOHIRO: "Skin-lightening preparations containing cinnamic acid derivatives" page 423; column 2; XP002900538
CHEMICAL ABSTRACTS, vol. 95, no. 19, 9 November 1981, Columbus, Ohio, US; abstract no. 161760z, IIZUKA KINJI ET AL.: "Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives" page 25; column 1; XP002900539
CHEMICAL ABSTRACTS, vol. 91, no. 25, 17 December 1979, Columbus, Ohio, US; abstract no. 210985e, PLEVYAK, J.E. ET AL.: "Selective palladium-catalyzed vinylic substitutions with bromoiodo aromatics" page 644; column 1; XP002900540
CHEMICAL ABSTRACTS, vol. 107, no. 21, 23 November 1987, Columbus, Ohio, US; abstract no. 190622c, GODA, YUKIHIRO ET AL.: "Inhibitors of the arachidonate cascade from Allium chinense and their effect on in vitro platelet aggregation" page 43; column 1; XP002900541
CHEMICAL ABSTRACTS, vol. 117, no. 5, 3 August 1992, Columbus, Ohio, US; abstract no. 39800v, TSENG, CHENFANG ET AL.: "Inhibition of in vitro prostaglandin and leukotriene biosyntheses by cinnamoyl-beta-phenethylamine and N-acyldopamine derivatives" page 20; column 1; XP002900542
CHEMICAL ABSTRACTS, vol. 109, no. 21, 21 November 1988, Columbus, Ohio, US; abstract no. 190191c, BUGGLE, K. ET AL.: "The reaction of diphenylsulfilimine with benzothiopyran-4-one 1,1-dioxides and benzothiopyran-2-ones" page 691; column 2; XP002900543
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