Title:
CAR.IL-33-T AND PREPARATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/205343
Kind Code:
A1
Abstract:
Provided in the present invention are CAR.IL-33-T cells and the preparation and application thereof, relating to the field of biotechnology. The chimeric antigen receptor T cells provided in the present invention express a chimeric antigen receptor (CAR) and interleukin-33 (IL-33) that target tumour antigens.
Inventors:
JIANG JINGTING (CN)
LU BINFENG (CN)
CHEN YU'ANG (CN)
CHEN LUJUN (CN)
LU BINFENG (CN)
CHEN YU'ANG (CN)
CHEN LUJUN (CN)
Application Number:
PCT/CN2017/088506
Publication Date:
November 15, 2018
Filing Date:
June 15, 2017
Export Citation:
Assignee:
FIRST PEOPLES HOSPITAL CHANGZHOU (CN)
International Classes:
C12N5/10; A61K35/17; A61P35/00; C12N15/62; C12N15/85
Domestic Patent References:
| WO2014130635A1 | 2014-08-28 |
Foreign References:
| CN104910279A | 2015-09-16 | |||
| CN101370827A | 2009-02-18 |
Other References:
HOMBACH, A. ET AL.: "Tumor-specific T Cell Activation by Recombinant Immunoreceptors: CD 3 Zeta Signaling and CD 28 Costimulation are Simultaneously Required for Efficient IL -2 Secretion and can be Integrated into One Combined CD 28/ CD 3 Zeta Signaling Receptor Molecule", JOURNAL OF IMMUNOLOGY, vol. 167, no. 11, 1 December 2001 (2001-12-01), XP055083123, DOI: doi:10.4049/jimmunol.167.11.6123
DENG, XU ET AL.: "non- official translation: Significance of IL -33 and Receptor ST2 thereof in Antiviral and Antitumor Immune Responses", CHINESE JOURNAL OF CLINICAL LABORATORY SCIENCE, vol. 33, no. 2, 12 February 2015 (2015-02-12), pages 131
SCHLIMPER, C. ET AL.: "Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells", CLINICAL AND DEVELOPMENTAL IMMUNOLOGY, vol. 49, no. 8, 19 March 2012 (2012-03-19), pages 441 - 448, XP055309532
DOMINGUEZ, D. ET AL.: "Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer", THE JOURNAL OF IMMUNOLOGY, vol. 198, no. 3, 23 December 2016 (2016-12-23), pages 1365 - 1375, XP055551251
DENG, XU ET AL.: "non- official translation: Significance of IL -33 and Receptor ST2 thereof in Antiviral and Antitumor Immune Responses", CHINESE JOURNAL OF CLINICAL LABORATORY SCIENCE, vol. 33, no. 2, 12 February 2015 (2015-02-12), pages 131
SCHLIMPER, C. ET AL.: "Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells", CLINICAL AND DEVELOPMENTAL IMMUNOLOGY, vol. 49, no. 8, 19 March 2012 (2012-03-19), pages 441 - 448, XP055309532
DOMINGUEZ, D. ET AL.: "Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer", THE JOURNAL OF IMMUNOLOGY, vol. 198, no. 3, 23 December 2016 (2016-12-23), pages 1365 - 1375, XP055551251
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (CN)
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