Title:
CCL21 BINDING MOLECULES
Document Type and Number:
WIPO Patent Application WO/2011/080050
Kind Code:
A3
Abstract:
The present invention relates to binding molecules, in particular antibodies and immunoglobulins to human CCL21 (hCCL21) and their use in the treatment and/or prevention of human diseases and disorders, particularly those of a fibrotic nature. Pharmaceutical compositions, methods of manufacture and methods of treatment are also disclosed.
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Inventors:
BARDROFF MICHAEL (CH)
EWERT STEFAN (CH)
JAEGER UTE (DE)
JARAI GABOR (GB)
KUNZ CHRISTIAN CARSTEN SILVESTER (DE)
WIESEHAN KATJA (DE)
EWERT STEFAN (CH)
JAEGER UTE (DE)
JARAI GABOR (GB)
KUNZ CHRISTIAN CARSTEN SILVESTER (DE)
WIESEHAN KATJA (DE)
Application Number:
PCT/EP2010/069430
Publication Date:
August 25, 2011
Filing Date:
December 10, 2010
Export Citation:
Assignee:
NOVARTIS AG (CH)
BARDROFF MICHAEL (CH)
EWERT STEFAN (CH)
JAEGER UTE (DE)
JARAI GABOR (GB)
KUNZ CHRISTIAN CARSTEN SILVESTER (DE)
WIESEHAN KATJA (DE)
BARDROFF MICHAEL (CH)
EWERT STEFAN (CH)
JAEGER UTE (DE)
JARAI GABOR (GB)
KUNZ CHRISTIAN CARSTEN SILVESTER (DE)
WIESEHAN KATJA (DE)
International Classes:
C07K16/24
Domestic Patent References:
| WO2007075592A2 | 2007-07-05 |
Other References:
MOXLEY R ET AL: "Cloning and pharmacological characterization of CCR7, CCL21 and CCL19 from Macaca fascicularis", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 3-4, 28 June 2009 (2009-06-28), pages 264 - 271, XP026160252, ISSN: 0928-0987, [retrieved on 20090306], DOI: DOI:10.1016/J.EJPS.2009.02.013
NAGIRA M ET AL: "MOLECULAR CLONING OF A NOVEL HUMAN CC CHEMOKINE SECONDARY LYMPHOID-TISSUE CHEMOKINE THAT IS A POTENT CHEMOATTRACTANT FOR LYMPHOCYTES AND MAPPED TO CHROMOSOME 9P13", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC., BALTIMORE, MD, US, vol. 272, no. 31, 1 August 1997 (1997-08-01), pages 19518 - 19524, XP002937425, ISSN: 0021-9258, DOI: DOI:10.1074/JBC.272.31.19518
WADA T ET AL: "Fibrocytes: a new insight into kidney fibrosis", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 72, no. 3, 1 August 2007 (2007-08-01), pages 269 - 273, XP009149767, ISSN: 0085-2538
WILEY HENRY E ET AL: "Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma", JOURNAL OF THE NATIONAL CANCER INSTITUTE, OXFORD UNIVERSITY PRESS, GB, vol. 93, no. 21, 1 January 2000 (2000-01-01), pages 1638 - 1643, XP009149768, ISSN: 0027-8874
SHIELDS J D ET AL: "Chemokine-mediated migration of melanoma cells towards lymphatics--a mechanism contributing to metastasis.", ONCOGENE 10 MAY 2007 LNKD- PUBMED:17130836, vol. 26, no. 21, 10 May 2007 (2007-05-10), pages 2997 - 3005, XP009149792, ISSN: 0950-9232
SAEKI H ET AL: "Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAR 1999 LNKD- PUBMED:10072485, vol. 162, no. 5, 1 March 1999 (1999-03-01), pages 2472 - 2475, XP009149791, ISSN: 0022-1767
LITTLE M ET AL: "Of mice and men: hybridoma and recombinant antibodies", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 8, 1 August 2000 (2000-08-01), pages 364 - 370, XP004215163, ISSN: 0167-5699, DOI: DOI:10.1016/S0167-5699(00)01668-6
SKERRA ET AL: "Alternative non-antibody scaffolds for molecular recognition", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 18, no. 4, 14 September 2007 (2007-09-14), pages 295 - 304, XP022244962, ISSN: 0958-1669, DOI: DOI:10.1016/J.COPBIO.2007.04.010
NAGIRA M ET AL: "MOLECULAR CLONING OF A NOVEL HUMAN CC CHEMOKINE SECONDARY LYMPHOID-TISSUE CHEMOKINE THAT IS A POTENT CHEMOATTRACTANT FOR LYMPHOCYTES AND MAPPED TO CHROMOSOME 9P13", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC., BALTIMORE, MD, US, vol. 272, no. 31, 1 August 1997 (1997-08-01), pages 19518 - 19524, XP002937425, ISSN: 0021-9258, DOI: DOI:10.1074/JBC.272.31.19518
WADA T ET AL: "Fibrocytes: a new insight into kidney fibrosis", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 72, no. 3, 1 August 2007 (2007-08-01), pages 269 - 273, XP009149767, ISSN: 0085-2538
WILEY HENRY E ET AL: "Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma", JOURNAL OF THE NATIONAL CANCER INSTITUTE, OXFORD UNIVERSITY PRESS, GB, vol. 93, no. 21, 1 January 2000 (2000-01-01), pages 1638 - 1643, XP009149768, ISSN: 0027-8874
SHIELDS J D ET AL: "Chemokine-mediated migration of melanoma cells towards lymphatics--a mechanism contributing to metastasis.", ONCOGENE 10 MAY 2007 LNKD- PUBMED:17130836, vol. 26, no. 21, 10 May 2007 (2007-05-10), pages 2997 - 3005, XP009149792, ISSN: 0950-9232
SAEKI H ET AL: "Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAR 1999 LNKD- PUBMED:10072485, vol. 162, no. 5, 1 March 1999 (1999-03-01), pages 2472 - 2475, XP009149791, ISSN: 0022-1767
LITTLE M ET AL: "Of mice and men: hybridoma and recombinant antibodies", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 8, 1 August 2000 (2000-08-01), pages 364 - 370, XP004215163, ISSN: 0167-5699, DOI: DOI:10.1016/S0167-5699(00)01668-6
SKERRA ET AL: "Alternative non-antibody scaffolds for molecular recognition", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 18, no. 4, 14 September 2007 (2007-09-14), pages 295 - 304, XP022244962, ISSN: 0958-1669, DOI: DOI:10.1016/J.COPBIO.2007.04.010
Attorney, Agent or Firm:
KASSOW, Anders (Patent Department, Basel, CH)
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