Title:
CELL CAPABLE OF PRODUCING ADENO-ASSOCIATED VIRUS VECTOR
Document Type and Number:
WIPO Patent Application WO/2014/007120
Kind Code:
A1
Abstract:
According to the present invention, an AAV vector having a higher titer compared with those of conventional ones can be produced using a cell into which a nucleic acid capable of expressing miRNA is introduced artificially. An AAV vector produced using the cell and a composition containing the virus vector as an active ingredient are very useful as gene transfer means in the studies or clinical practice of gene therapies.
More Like This:
| WO/2002/028878 | ANTISENSE MODULATION OF SMAD6 EXPRESSION |
| WO/2023/087062 | METHOD FOR TREATING CYCLOPHILIN B ASSOCIATED DISEASES |
| WO/2007/022470 | METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE |
Inventors:
NISHIE TOSHIKAZU (JP)
TAKASHIMA FUYUKO (JP)
ENOKI TATSUJI (JP)
MINENO JUNICHI (JP)
TAKASHIMA FUYUKO (JP)
ENOKI TATSUJI (JP)
MINENO JUNICHI (JP)
Application Number:
PCT/JP2013/067488
Publication Date:
January 09, 2014
Filing Date:
June 26, 2013
Export Citation:
Assignee:
TAKARA BIO INC (JP)
International Classes:
C12N15/113; C12N5/10; C12N15/09
Domestic Patent References:
| WO2001032899A1 | 2001-05-10 | |||
| WO2006035829A1 | 2006-04-06 | |||
| WO2009148137A1 | 2009-12-10 | |||
| WO1997006272A2 | 1997-02-20 | |||
| WO2006035829A1 | 2006-04-06 |
Foreign References:
| JP2001517454A | 2001-10-09 | |||
| JP2001520051A | 2001-10-30 | |||
| US6093570A | 2000-07-25 |
Other References:
KAMBARA, H. ET AL.: "Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122", J. VIROL., vol. 86, no. 3, 2011, pages 1382 - 1393, XP055181583
MUNSON, D. J. ET AL.: "A novel miRNA produced during lytic HSV-1 infection is important for efficient replication in tissue culture", ARCH. VIROL., vol. 157, June 2012 (2012-06-01), pages 1677 - 1688, XP035105657
APARICIO, O. ET AL.: "Adenovirus virus- associated RNA is processed to functional interfering RNAs involved in virus production", J. VIROL., vol. 80, no. 3, 2006, pages 1376 - 1384, XP055181585
RANDALL, G. ET AL.: "Cellular cofactors affecting hepatitis C virus infection and replication", PROC. NATL. ACAD. SCI. U S A., vol. 104, no. 31, 2007, pages 12884 - 12889, XP002532652
HUSSAIN, M. ET AL.: "West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells", NUCLEIC ACIDS RES., vol. 40, no. 5, 2011, pages 2210 - 2223, XP055181588
OZAWA, K.: "Gene therapy using AAV (adeno- associated virus) vectors", VIRUS, vol. 53, no. 2, 2003, pages 163 - 170, XP055181594
PROC. NATL. ACAD. SCI. USA, vol. 107, 2010, pages 10220 - 10225
See also references of EP 2871239A4
MUNSON, D. J. ET AL.: "A novel miRNA produced during lytic HSV-1 infection is important for efficient replication in tissue culture", ARCH. VIROL., vol. 157, June 2012 (2012-06-01), pages 1677 - 1688, XP035105657
APARICIO, O. ET AL.: "Adenovirus virus- associated RNA is processed to functional interfering RNAs involved in virus production", J. VIROL., vol. 80, no. 3, 2006, pages 1376 - 1384, XP055181585
RANDALL, G. ET AL.: "Cellular cofactors affecting hepatitis C virus infection and replication", PROC. NATL. ACAD. SCI. U S A., vol. 104, no. 31, 2007, pages 12884 - 12889, XP002532652
HUSSAIN, M. ET AL.: "West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells", NUCLEIC ACIDS RES., vol. 40, no. 5, 2011, pages 2210 - 2223, XP055181588
OZAWA, K.: "Gene therapy using AAV (adeno- associated virus) vectors", VIRUS, vol. 53, no. 2, 2003, pages 163 - 170, XP055181594
PROC. NATL. ACAD. SCI. USA, vol. 107, 2010, pages 10220 - 10225
See also references of EP 2871239A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
Download PDF: