Title:
CELL CULTURE DEVICE AND CULTURE METHOD
Document Type and Number:
WIPO Patent Application WO/2021/199529
Kind Code:
A1
Abstract:
Provided is a cell culture device equipped with: a culture tank having a capacity of 0.5-50 L; a separator tube positioned extending from the inside to the outside of the culture tank, the separator tube having an inside diameter of 0.5-5 cm; a pump connected to the separator tube; an intake port and an exhaust port provided in the culture tank; a medium supply port provided in the culture tank; and an adjustment tool provided on at least part of the separator tube, the adjustment tool adjusting the separator tube to 30-45°C.
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Inventors:
MARUYAMA MASASHI (JP)
SATO YUSHI (JP)
TADA YASUHIKO (JP)
SUZUKI YUMA (JP)
OKANOJO MASAHIRO (JP)
CHEN SHANGWU (JP)
TAKAHASHI RYOSUKE (JP)
SATO YUSHI (JP)
TADA YASUHIKO (JP)
SUZUKI YUMA (JP)
OKANOJO MASAHIRO (JP)
CHEN SHANGWU (JP)
TAKAHASHI RYOSUKE (JP)
Application Number:
PCT/JP2020/047727
Publication Date:
October 07, 2021
Filing Date:
December 21, 2020
Export Citation:
Assignee:
SHOWA DENKO MATERIALS CO LTD (JP)
International Classes:
C12M1/34; C12M3/00; C12N5/02; C12N5/071
Domestic Patent References:
| WO2013161885A1 | 2013-10-31 | |||
| WO2007071072A1 | 2007-06-28 | |||
| WO2017192966A1 | 2017-11-09 |
Foreign References:
| JP2005205396A | 2005-08-04 | |||
| JPH06209761A | 1994-08-02 | |||
| JPS575690A | 1982-01-12 | |||
| JP2011529331A | 2011-12-08 |
Other References:
GE HEALTHCARE LIFE SCIENCES: "A microcarrier cell culture handbook", 6 February 2014 (2014-02-06), pages 1 - 172, XP009537012, Retrieved from the Internet
AMAL EL WAJGALI;FRANTZ FOURNIER;ERIC OLMOS;CÉCILE GÉNY;HERVÉ PINTON;ANNIE MARC : "Influence of operating parameters of a settling-based perfusion process on expansion of VERO cells attached on microcarriers", BMC PROCEEDINGS, BIOMED CENTRAL LTD, LONDON UK, vol. 5, no. Suppl 8, 22 November 2011 (2011-11-22), London UK , pages P60, XP021114438, ISSN: 1753-6561, DOI: 10.1186/1753-6561-5-S8-P60
KEITH J THOMPSON, JAMES S WILSON: "A compact gravitational settling device for cell retention", ANIMAL CELL TECHNOLOGY : PRODUCTS OF TODAY, PROSPECTS FOR TOMORROW ; ESACT, EUROPEAN SOCIETY FOR ANIMAL CELL TECHNOLOGY, THE 12TH MEETING; WÜRZBURG, GERMANY : [1993.05.17-21], 1 May 1994 (1994-05-01) - 21 May 1993 (1993-05-21), Oxford ; Munich, pages 227 - 229, XP009537001, ISBN: 0-7506-1845-0, DOI: 10.1016/B978-0-7506-1845-8.50055-7
BUTLER M., IMAMURA T., THOMAS J., THILLY W.G.: "High yields from microcarrier cultures by medium perfusion", JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LIMITED, CAMBRIDGE, vol. 61, no. 1, 1 May 1983 (1983-05-01), Cambridge , pages 351 - 363, XP055935579, ISSN: 0021-9533, DOI: 10.1242/jcs.61.1.351
KAMBAYASHI TAKUYA, NOGUCHI TOSHIMITSU, NOJIMA AKIHIRO, KONO SHUNSUKE, TANIGUCHI SHIN-ICHI, OZAKI YUKIHIRO: "Glucose Monitoring in Cell Culture with Online Ultrasound-Assisted Near-Infrared Spectroscopy", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 92, no. 4, 18 February 2020 (2020-02-18), US , pages 2946 - 2952, XP055935583, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b03354
"New Insights into Cell Culture Technology", 10 May 2017, INTECH , ISBN: 978-953-51-3134-2, article ELSEBERG CHRISTIANE, LEBER JASMIN, WEIDNER TOBIAS, CZERMAK PETER: "The Challenge of Human Mesenchymal Stromal Cell Expansion: Current and Prospective Answers", pages: 99 - 134, XP055935584, DOI: 10.5772/66901
SHIBUYA, KEISUKE ET AL.: "Perfusion culture of CHO cells using thermoresponsive-polymer-modified insuline", ABSTRACTS OF THE ANNUAL MEETING OF THE CHEMICAL ENGINEERING SOCIETY, vol. 85 th, May 2020 (2020-05-01)
AMAL EL WAJGALI;FRANTZ FOURNIER;ERIC OLMOS;CÉCILE GÉNY;HERVÉ PINTON;ANNIE MARC : "Influence of operating parameters of a settling-based perfusion process on expansion of VERO cells attached on microcarriers", BMC PROCEEDINGS, BIOMED CENTRAL LTD, LONDON UK, vol. 5, no. Suppl 8, 22 November 2011 (2011-11-22), London UK , pages P60, XP021114438, ISSN: 1753-6561, DOI: 10.1186/1753-6561-5-S8-P60
KEITH J THOMPSON, JAMES S WILSON: "A compact gravitational settling device for cell retention", ANIMAL CELL TECHNOLOGY : PRODUCTS OF TODAY, PROSPECTS FOR TOMORROW ; ESACT, EUROPEAN SOCIETY FOR ANIMAL CELL TECHNOLOGY, THE 12TH MEETING; WÜRZBURG, GERMANY : [1993.05.17-21], 1 May 1994 (1994-05-01) - 21 May 1993 (1993-05-21), Oxford ; Munich, pages 227 - 229, XP009537001, ISBN: 0-7506-1845-0, DOI: 10.1016/B978-0-7506-1845-8.50055-7
BUTLER M., IMAMURA T., THOMAS J., THILLY W.G.: "High yields from microcarrier cultures by medium perfusion", JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LIMITED, CAMBRIDGE, vol. 61, no. 1, 1 May 1983 (1983-05-01), Cambridge , pages 351 - 363, XP055935579, ISSN: 0021-9533, DOI: 10.1242/jcs.61.1.351
KAMBAYASHI TAKUYA, NOGUCHI TOSHIMITSU, NOJIMA AKIHIRO, KONO SHUNSUKE, TANIGUCHI SHIN-ICHI, OZAKI YUKIHIRO: "Glucose Monitoring in Cell Culture with Online Ultrasound-Assisted Near-Infrared Spectroscopy", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 92, no. 4, 18 February 2020 (2020-02-18), US , pages 2946 - 2952, XP055935583, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b03354
"New Insights into Cell Culture Technology", 10 May 2017, INTECH , ISBN: 978-953-51-3134-2, article ELSEBERG CHRISTIANE, LEBER JASMIN, WEIDNER TOBIAS, CZERMAK PETER: "The Challenge of Human Mesenchymal Stromal Cell Expansion: Current and Prospective Answers", pages: 99 - 134, XP055935584, DOI: 10.5772/66901
SHIBUYA, KEISUKE ET AL.: "Perfusion culture of CHO cells using thermoresponsive-polymer-modified insuline", ABSTRACTS OF THE ANNUAL MEETING OF THE CHEMICAL ENGINEERING SOCIETY, vol. 85 th, May 2020 (2020-05-01)
Attorney, Agent or Firm:
MIYOSHI Hidekazu et al. (JP)
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