Title:
CELL CULTURING SYSTEM, SENSOR KIT, AND METHOD OF DETERMINING LIFESPAN OF ENZYME SENSOR
Document Type and Number:
WIPO Patent Application WO/2021/161927
Kind Code:
A1
Abstract:
A cell culturing system (22) includes an enzyme sensor (124) that detects a concentration of a predetermined component of a culture medium used for culturing of cells, a sensor flow path (46B2) in which the enzyme sensor (124) is disposed, and a bioreactor (20) that performs culturing of cells while causing the culture medium to flow through the sensor flow path (46B2), and further includes a deterioration index calculation unit (138) that determines a deterioration index of the enzyme sensor (124), based on a detected concentration value of the enzyme sensor (124), and a detection period during which the detected concentration value is detected, and a lifespan determination unit (140) that detects whether or not an integrated value of the deterioration index has reached a threshold value, and thereby determines the lifespan of the enzyme sensor (124).
Inventors:
IGARASHI MASATSUGU (JP)
Application Number:
PCT/JP2021/004386
Publication Date:
August 19, 2021
Filing Date:
February 05, 2021
Export Citation:
Assignee:
TERUMO CORP (JP)
International Classes:
C12M1/12; C12M1/00; C12M1/34; C12M1/36; C12Q1/00
Foreign References:
| US20190352589A1 | 2019-11-21 | |||
| JP2010019569A | 2010-01-28 | |||
| US20050112549A1 | 2005-05-26 | |||
| US5082786A | 1992-01-21 | |||
| JP2017143775A | 2017-08-24 | |||
| JPS62240848A | 1987-10-21 |
Other References:
GAIA ROCCHITTA ET AL: "Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids", SENSORS, vol. 16, no. 780, 1 January 2016 (2016-01-01), pages 1 - 21, XP055641156, DOI: 10.3390/s16060780
Attorney, Agent or Firm:
CHIBA Yoshihiro et al. (JP)
Download PDF: