Title:
CELL LYSIS SOLUTION OF ENGINEERING BACTERIUM AND USE THEREOF IN TUMOR THERAPY
Document Type and Number:
WIPO Patent Application WO/2022/094847
Kind Code:
A1
Abstract:
A cell lysis solution of an engineering bacterium, particularly a cell lysis solution of a facultative anaerobic bacterium that knocks out the dapA gene or the dapE gene, and the use thereof in tumor therapy.
Inventors:
LIU CHENLI (CN)
WANG ZUOWEI (CN)
SHENG FANGQIAN (CN)
GUO XUAN (CN)
ZENG ZHENGYANG (CN)
DONG YUXUAN (CN)
LU WEIQI (CN)
LI YANG (CN)
HUANG XIONGLIANG (CN)
ZHENG HAI (CN)
LIU WEIRONG (CN)
WANG ZUOWEI (CN)
SHENG FANGQIAN (CN)
GUO XUAN (CN)
ZENG ZHENGYANG (CN)
DONG YUXUAN (CN)
LU WEIQI (CN)
LI YANG (CN)
HUANG XIONGLIANG (CN)
ZHENG HAI (CN)
LIU WEIRONG (CN)
Application Number:
PCT/CN2020/126718
Publication Date:
May 12, 2022
Filing Date:
November 05, 2020
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K35/74; C12N1/06; A61P35/00; C12R1/42
Domestic Patent References:
| WO2020014543A2 | 2020-01-16 |
Foreign References:
| CN103215291A | 2013-07-24 | |||
| CN105018403A | 2015-11-04 | |||
| CN108660148A | 2018-10-16 | |||
| CN111019878A | 2020-04-17 | |||
| CN110693917A | 2020-01-17 |
Other References:
GWEE CHIN PIAW, KHOO CHAI HOON, YEAP SWEE KEONG, TAN GEOK CHIN, CHEAH YOKE KQUEEN: "Targeted inactivation of Salmonella Agona metabolic genes by group II introns and in vivo assessment of pathogenicity and anti-tumour activity in mouse model", PEERJ, vol. 7, 16 January 2019 (2019-01-16), pages e5989, XP055927611, DOI: 10.7717/peerj.5989
GUO CHENG-XUAN, WANG HUA-PENG, BAI YIN-LAN: "Advances in application of Salmonella in tumor bio-therapy", PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY, CN, vol. 48, no. 4, 31 August 2020 (2020-08-31), CN , pages 74 - 80, XP055927590, ISSN: 1005-5673, DOI: 10.13309/j.cnki.pmi.2020.04.012
GUO CHENG-XUAN, WANG HUA-PENG, BAI YIN-LAN: "Advances in application of Salmonella in tumor bio-therapy", PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY, CN, vol. 48, no. 4, 31 August 2020 (2020-08-31), CN , pages 74 - 80, XP055927590, ISSN: 1005-5673, DOI: 10.13309/j.cnki.pmi.2020.04.012
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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