CELL PREPARATION - FOUNDATION FOR BIOMEDICAL RES AND INNOVATION AT KOBE

Title:

CELL PREPARATION

Document Type and Number:

WIPO Patent Application WO/2023/181830

Kind Code:

A1

Abstract:

Provided is a cell preparation that has effective therapeutic effect on ischemic diseases. The cell preparation contains CD18-positive cells. This cell preparation is produced by: acquiring a buffy coat layer from a sample containing hematopoietic stem cells; removing inhibitory cells that inhibit the therapeutic effect from the buffy coat layer to acquire mononuclear cells; acquiring CD34+ mononuclear cells that are CD34-positive from the mononuclear cells; and then acquiring CD34+CD18high mononuclear cells that highly express CD18 from the CD34-positive mononuclear cells.

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Inventors:

TAGUCHI AKIHIKO (JP)
OKINAKA YUKA (JP)
OGAWA YUKO (JP)
KIMURA TAKAFUMI (JP)
TANAKA MITSUNOBU (JP)
YASUI KAZUTA (JP)
FUCHIZAKI AKIHIRO (JP)

Application Number:

PCT/JP2023/007766

Publication Date:

September 28, 2023

Filing Date:

March 02, 2023

Export Citation:

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Assignee:

FOUNDATION FOR BIOMEDICAL RES AND INNOVATION AT KOBE (JP)

International Classes:

A61K35/12; A61K35/28; A61K35/51; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C12N5/0735; C12N5/074; C12N5/0775; C12N5/0789; C12N5/0797; C12N5/10

Foreign References:

US20070248998A1	2007-10-25
US20070031387A1	2007-02-08

Other References:

AKIHIKO TAGUCHI, TOSHIHIRO SOMA, HIDEKAZU TANAKA, TAKAYOSHI KANDA, HIROYUKI NISHIMURA, HIROO YOSHIKAWA, YOSHITANE TSUKAMOTO, HIROY: "Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 114, no. 3, 1 August 2004 (2004-08-01), GB , pages 330 - 338, XP008146070, ISSN: 0021-9738, DOI: 10.1172/JCI20622
MESA-NÚÑEZ CRISTINA, LEON-RICO DIEGO, ALDEA MONTSERRAT, DAMIÁN CARLOS, SANCHEZ-BALTASAR RAQUEL, SANCHEZ REBECA, ALBERQUILLA OMAIRA: "The downregulated membrane expression of CD18 in CD34+ cells defines a primitive population of human hematopoietic stem cells", STEM CELL RESEARCH & THERAPY, vol. 11, no. 1, 1 December 2020 (2020-12-01), pages 1 - 9, XP093095764, DOI: 10.1186/s13287-020-01672-0

Attorney, Agent or Firm:

MAEDA & PARTNERS (JP)

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