Title:
CELLS CAPABLE OF DIFFERENTIATING INTO CARDIAC MUSCLE CELLS
Document Type and Number:
WIPO Patent Application WO/2006/078034
Kind Code:
A1
Abstract:
Cells capable of differentiating into cardiac muscle cells which originate in the uterus membrane obtained from the endometrial membrane or menstrual blood or mesenchymal stem cells separated from menstrual blood, cord blood or appendages of a fetus. The above-described cells can be relatively easily acquired and obtained from, for example, menstrual blood or cord blood, which can supply a large number of HLA types, or appendages of a fetus to be discharged after the birth. When cocultured with cardiac muscle cells, these cells differentiate into cardiac muscle cells at a high frequency. Moreover, the differentiation thereof into cardiac muscle cells arises at a high frequency without demethylating (for example, by treating with 5-azacitidine) immortalized cells. By using the above-described cells, a drug for heart regeneration or a remedy for heart diseases can be provided.
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Inventors:
UMEZAWA AKIHIRO (JP)
MIYOSHI SHUNICHIRO (JP)
OGAWA SATOSHI (JP)
MIYOSHI SHUNICHIRO (JP)
OGAWA SATOSHI (JP)
Application Number:
PCT/JP2006/301043
Publication Date:
July 27, 2006
Filing Date:
January 24, 2006
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND (JP)
UMEZAWA AKIHIRO (JP)
MIYOSHI SHUNICHIRO (JP)
OGAWA SATOSHI (JP)
UMEZAWA AKIHIRO (JP)
MIYOSHI SHUNICHIRO (JP)
OGAWA SATOSHI (JP)
International Classes:
A61K35/34; A61K35/51; A61K35/54; A61P9/00; A61P9/04; A61P9/10; C07K16/28; C12N5/077; C12N5/10; C12P21/02; C12Q1/02; C12N15/09
Foreign References:
| JP2003033179A | 2003-02-04 |
Other References:
MAKINO S. ET AL.: "Cardiomyocytes can be generated from marrow stromal cells in vitro", J. CLIN. INVEST., vol. 103, no. 5, 1999, pages 697 - 705, XP000990317
TOMA C. ET AL.: "Human Mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart", CIRCULATION, vol. 105, no. 1, 2002, pages 93 - 98, XP002984364
UMEZAWA A. ET AL.: "Tanri Kanyokei Kansaibo no Shinkin Saibo eno Bunka", SEITAI NO KAGAKU, vol. 55, no. 4, 2004, pages 329 - 333, XP003004067
UMEZAWA A.: "Kanyokei Kansaibo karano Kinkokkakukei eno Bunka", vol. 15, no. 5, April 2005 (2005-04-01), pages 805 - 812, XP003004068
TOMA C. ET AL.: "Human Mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart", CIRCULATION, vol. 105, no. 1, 2002, pages 93 - 98, XP002984364
UMEZAWA A. ET AL.: "Tanri Kanyokei Kansaibo no Shinkin Saibo eno Bunka", SEITAI NO KAGAKU, vol. 55, no. 4, 2004, pages 329 - 333, XP003004067
UMEZAWA A.: "Kanyokei Kansaibo karano Kinkokkakukei eno Bunka", vol. 15, no. 5, April 2005 (2005-04-01), pages 805 - 812, XP003004068
Attorney, Agent or Firm:
Yoshitake, Kenji (Room 323 Fuji Bldg., 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo 05, JP)
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