Title:
CELLS, VERTEBRATES, POPULATIONS & METHODS
Document Type and Number:
WIPO Patent Application WO/2019/008123
Kind Code:
A3
Abstract:
The invention relates to cells and non-human vertebrates for producing antibody chains (eg, truly common L or H chains), in particular for use in producing multi-specific antibodies useful for therapy or diagnosis.
Inventors:
LEE E-CHIANG (GB)
WANG WEI (GB)
BLACKWOOD JOHN KENNETH (GB)
MAGLIOZZI ROBERTO (GB)
WANG WEI (GB)
BLACKWOOD JOHN KENNETH (GB)
MAGLIOZZI ROBERTO (GB)
Application Number:
PCT/EP2018/068309
Publication Date:
February 14, 2019
Filing Date:
July 05, 2018
Export Citation:
Assignee:
KYMAB LTD (GB)
International Classes:
C12N15/85; A01K67/027
Foreign References:
| US20120021409A1 | 2012-01-26 |
Other References:
MATTHEW A. INLAY ET AL: "Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 203, no. 7, 10 July 2006 (2006-07-10), US, pages 1721 - 1732, XP055516424, ISSN: 0022-1007, DOI: 10.1084/jem.20052310
DIAZ M ET AL: "Somatic immunoglobulin hypermutation", CURRENT OPINION IN IMMUNOL, ELSEVIER, OXFORD, GB, vol. 14, no. 2, 1 April 2002 (2002-04-01), pages 235 - 240, XP004340052, ISSN: 0952-7915, DOI: 10.1016/S0952-7915(02)00327-8
T. PERLOT ET AL: "Elucidation of IgH intronic enhancer functions via germ-line deletion", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 40, 4 October 2005 (2005-10-04), pages 14362 - 14367, XP055516419, ISSN: 0027-8424, DOI: 10.1073/pnas.0507090102
WINTER D B ET AL: "Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 34, no. 5, 1 April 1997 (1997-04-01), pages 359 - 366, XP002556634, ISSN: 0161-5890, [retrieved on 19971010], DOI: 10.1016/S0161-5890(97)00073-4
DIAZ M ET AL: "Somatic immunoglobulin hypermutation", CURRENT OPINION IN IMMUNOL, ELSEVIER, OXFORD, GB, vol. 14, no. 2, 1 April 2002 (2002-04-01), pages 235 - 240, XP004340052, ISSN: 0952-7915, DOI: 10.1016/S0952-7915(02)00327-8
T. PERLOT ET AL: "Elucidation of IgH intronic enhancer functions via germ-line deletion", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 40, 4 October 2005 (2005-10-04), pages 14362 - 14367, XP055516419, ISSN: 0027-8424, DOI: 10.1073/pnas.0507090102
WINTER D B ET AL: "Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 34, no. 5, 1 April 1997 (1997-04-01), pages 359 - 366, XP002556634, ISSN: 0161-5890, [retrieved on 19971010], DOI: 10.1016/S0161-5890(97)00073-4
Attorney, Agent or Firm:
CMS CAMERON MCKENNA NABARRO OLSWANG LLP (GB)
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