CELLULOSE GEL FOR PURIFICATION OF IMMUNOGLOBULIN

WIPO Patent Application WO/2010/095673

A1

Disclosed is a chromatography packing material wherein both flow rate and adsorption characteristics are improved. Disclosed is a chromatography packing material that is particularly suited to the isolation and purification of immunoglobulin in the manufacture of antibody pharmaceuticals. A porous cellulose gel, made by adding polysaccharides with limiting viscosity of 0.21‑0.90 L/g to porous cellulose particles, is used, and the dry weight per unit volume of the aforementioned porous cellulose gel is 1.06‑1.40 times the dry weight per unit volume of the aforementioned porous cellulose particles. Flow rate and adsorption characteristics can be improved by adding a specified quantity of polysaccharides with a specified limiting viscosity to the porous cellulose particles.

MATSUMOTO YOSHIHIRO (JP)
UMEDA YASUTO (JP)
AOYAMA SHIGEYUKI (JP)
TODOKORO MASAMI (JP)

PCT/JP2010/052407

August 26, 2010

February 18, 2010

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CHISSO CORP (JP)
MATSUMOTO YOSHIHIRO (JP)
UMEDA YASUTO (JP)
AOYAMA SHIGEYUKI (JP)
TODOKORO MASAMI (JP)

G01N30/88; A61K39/395; B01D15/08; B01J20/24; B01J39/22; C07K1/18; C07K16/00

JP2009506340A	2009-02-12
JPH03277967A	1991-12-09
JPH01258739A	1989-10-16
JPS60500539A	1985-04-18

MELANI C.STONE ET AL.: "Protein adsorption and transport in agarose and dextran-grafted agarose media for ion exchange chromatography", JOURNAL OF CHROMATOGRAPHY A, vol. 1146, no. 2, 6 April 2007 (2007-04-06), pages 202 - 215

KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)

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