Title:
CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1999011605
Kind Code:
A8
Abstract:
Disclosed are the compounds of formula (I), wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; pharmaceutically acceptable salts thereof; and pharmaceutically acceptable prodrug esters thereof; as selective COX-2 cyclooxygenase inhibitors.
Inventors:
FUJIMOTO ROGER AKI
MCQUIRE LESLIE WIGHTON
MUGRAGE BENJAMIN BIRO
VAN DUZER JOHN HENRY
XU DAQIANG
MCQUIRE LESLIE WIGHTON
MUGRAGE BENJAMIN BIRO
VAN DUZER JOHN HENRY
XU DAQIANG
Application Number:
PCT/EP1998/005414
Publication Date:
March 02, 2000
Filing Date:
August 26, 1998
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
NOVARTIS ERFIND VERWALT GMBH (AT)
International Classes:
A61K31/196; A61K31/195; A61K31/216; A61P19/02; A61P25/04; A61P27/02; A61P29/00; C07C229/42; (IPC1-7): C07C229/42; A61K31/195
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