Title:
INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE
Document Type and Number:
WIPO Patent Application WO1999011606
Kind Code:
A3
Abstract:
The present invention comprises small molecular weight, non-peptidic inhibitors of formula (I) and (II) of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
Inventors:
LARSEN SCOTT D (US)
MAY PAUL D (US)
BLEASDALE JOHN (US)
LILJEBRIS CHARLOTTA (SE)
SCHOSTAREZ HEINRICH JOSEF (US)
BARF TJEERD (SE)
MAY PAUL D (US)
BLEASDALE JOHN (US)
LILJEBRIS CHARLOTTA (SE)
SCHOSTAREZ HEINRICH JOSEF (US)
BARF TJEERD (SE)
Application Number:
PCT/US1998/017327
Publication Date:
July 08, 1999
Filing Date:
August 24, 1998
Export Citation:
Assignee:
UPJOHN CO (US)
LARSEN SCOTT D (US)
MAY PAUL D (US)
BLEASDALE JOHN (US)
LILJEBRIS CHARLOTTA (SE)
SCHOSTAREZ HEINRICH JOSEF (US)
BARF TJEERD (SE)
LARSEN SCOTT D (US)
MAY PAUL D (US)
BLEASDALE JOHN (US)
LILJEBRIS CHARLOTTA (SE)
SCHOSTAREZ HEINRICH JOSEF (US)
BARF TJEERD (SE)
International Classes:
A61K31/197; A61K31/215; A61K31/4453; A61K31/495; A61K31/5375; A61K38/00; A61P3/10; A61P43/00; C07C233/18; C07C235/34; C07C235/74; C07D295/12; C07C235/80; C07C237/22; C07C237/52; C07C271/02; C07C271/22; C07C275/24; C07C275/42; C07C305/24; C07C311/06; C07C311/13; C07C311/37; C07C311/46; C07C311/47; C07C317/50; C07C323/59; C07D295/13; C07D295/20; C07D295/215; C07D521/00; C07K5/06; C07K5/065; C07K5/068; C07K5/072; C07K5/078; (IPC1-7): C07C237/22; C07C237/20; C07C235/78; C07C305/24; C07D257/04; C07D207/20; A61K31/165; A61K31/195; A61K31/41; A61K31/40; C07K5/06
Domestic Patent References:
| WO1996030332A1 | 1996-10-03 | |||
| WO1996033968A1 | 1996-10-31 | |||
| WO1996038415A1 | 1996-12-05 | |||
| WO1998007699A1 | 1998-02-26 |
Foreign References:
| DD151304A1 | 1981-10-14 | |||
| DE2320387A1 | 1974-10-31 |
Other References:
PAUL S. CHARIFSON ET AL.: "Peptide ligands of pp60c-src SH2 Domains: A thermodynamic and structural study", BIOCHEMISTRY., vol. 36, 1997, EASTON, PA US, pages 6283 - 6293, XP002087254
KING F D: "BIOISOSTERES, CONFORMATIONAL RESTRICTION, AND PRO-DRUGS - CASE HISTORY: AN EXAMPLE OF A CONFORMATIONAL RESTRICTION APPROACH", 1994, MEDICINAL CHEMISTRY: PRINCIPLES AND PRACTICE, PAGE(S) 206 - 209, KING F D, XP002033086
KING F D: "BIOISOSTERES, CONFORMATIONAL RESTRICTION, AND PRO-DRUGS - CASE HISTORY: AN EXAMPLE OF A CONFORMATIONAL RESTRICTION APPROACH", 1994, MEDICINAL CHEMISTRY: PRINCIPLES AND PRACTICE, PAGE(S) 206 - 209, KING F D, XP002033086
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