Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
CHIMERIC ANTIGEN RECEPTORS SPECIFICALLY BINDING TO MSLN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/131063
Kind Code:
A1
Abstract:
A bispecific antigen-binding molecule specifically binding to MSLN and NKG2D ligand (NKG2DL), a bispecific chimeric antigen receptor containing the bispecific antigen-binding molecule, a modified immune cell expressing the bispecific chimeric antigen receptor, and a method for preparing the modified immune cell. A modified immune cell that co-express an MSLN-specific CAR and an additional bioactive molecule, such as a PD-1 antibody and/or RIL-15, or NKG2D or an active fragment, and a method for preparing the modified immune cell. The bispecific antigen-binding molecules, CAR and immune cells are used for preventing and/or treating diseases related to the expression of mesothelin, such as malignant pleural mesothelioma, pancreatic cancer, lung cancer, breast cancer, ovarian cancer and other cancers.

Inventors:
ZHU YANLIN (CN)
CHANG JIANHUI (CN)
WU ZIMING (CN)
CAI ZHENZHEN (CN)
WANG JIANGMAN (CN)
YAN ZHONGHUI (CN)
OUYANG XUENONG (CN)
GE JUNYOU (CN)
Application Number:
PCT/CN2022/143718
Publication Date:
July 13, 2023
Filing Date:
December 30, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
CHENGDU KELUN PREC BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K16/46; A61K39/00; A61K45/06; A61P35/00
Domestic Patent References:
WO2020232433A12020-11-19
WO2017021356A12017-02-09
Foreign References:
CN107106665A2017-08-29
CN109069597A2018-12-21
CN110603265A2019-12-20
US20200360437A12020-11-19
US20210309755A12021-10-07
CN108219004A2018-06-29
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: COMMUNICATION METHOD AND COMMUNICATION APPARATUS FOR STREAM CLASSIFICATION SERVICE

Next Patent: JUNCTION BOX