Title:
CHIMERIC PANCREAS
Document Type and Number:
WIPO Patent Application WO2003083064
Kind Code:
A3
Abstract:
Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said tissue into the peritoneal cavity of a mammalian recipient under conditions that allow the pancreatic tissue to become vascularized and mature, thereby developing a functioning chimeric, endocrine pancreas that produces at least insulin in the recipient. The invention also includes mammalian immature pancreatic tissue adapted for transplantation into the peritoneal cavity of a mammalian recipient for increasing the pancreatic mass of the mammalian recipient as well as methods and compositions for treatment of the pancreatic tissue, recipient immunosuppression and recipient co-stimulatory blockade.
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Inventors:
HAMMERMAN MARC R (US)
Application Number:
PCT/US2003/009091
Publication Date:
March 25, 2004
Filing Date:
March 24, 2003
Export Citation:
Assignee:
UNIV WASHINGTON (US)
HAMMERMAN MARC R (US)
HAMMERMAN MARC R (US)
International Classes:
A61K35/12; A61K35/39; A61L27/00; A61P3/10; C07K16/28; C12N5/071; (IPC1-7): C12N5/00
Foreign References:
| US5593673A | 1997-01-14 |
Other References:
See also references of EP 1487967A4
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