Title:
CHONDROCYTE CULTURES AND ANTI-ANGIOGENIC FRACTIONS THEREFROM
Document Type and Number:
WIPO Patent Application WO2001083707
Kind Code:
A3
Abstract:
The present invention concerns the development of anti-angiogenic, anti-inflammatoric, lysozomic and/or anti-collagenolytic agents and/or collagen and/or chondroitinsulphate from cultured chondrocytes. The chondrocytes are collected from a wide variety of animals, preferably elasmobranches cartilage and a detailed culturing procedure is described. The cartilage may be obtained from dead animals or as a biopsy from living animals. Then the chondrocytes are denuded from the extracellular matrix. Thereafter the chondrocytes are cultured to produce the agents, which are then isolated and purified.
Inventors:
OLSEN OLE (DK)
ALBRECHTSEN MORTEN (DK)
DALKIAER MIKKEL (DK)
LITTLE MARIE-LOUISE OERBECH (DK)
ALBRECHTSEN MORTEN (DK)
DALKIAER MIKKEL (DK)
LITTLE MARIE-LOUISE OERBECH (DK)
Application Number:
PCT/DK2001/000297
Publication Date:
April 18, 2002
Filing Date:
May 01, 2001
Export Citation:
Assignee:
MEDICO KEMISK LAB (DK)
OLSEN OLE (DK)
ALBRECHTSEN MORTEN (DK)
DALKIAER MIKKEL (DK)
LITTLE MARIE LOUISE OERBECH (DK)
OLSEN OLE (DK)
ALBRECHTSEN MORTEN (DK)
DALKIAER MIKKEL (DK)
LITTLE MARIE LOUISE OERBECH (DK)
International Classes:
A61K35/32; A61K35/64; A61K38/39; C12N5/00; C12N5/077; C12P21/00; (IPC1-7): C12N5/06; A61K35/32; A61K38/39; C12P21/00
Domestic Patent References:
| WO1981003031A1 | 1981-10-29 | |||
| WO1998017791A1 | 1998-04-30 |
Other References:
C F O'HARA ET AL: "Cultured shark chondrocytes secrete an angiogenesis inhibitor", SOCIETY FOR IN VITRO BIOLOGY MEETING SAN FRANCISCO 1996, 1996, XP002901907
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