Title:
CLASS OF COMPOUNDS HAVING PYRIMIDO-SIX-MEMBERED RING STRUCTURE, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246837
Kind Code:
A1
Abstract:
The present invention relates to a class of compounds having a pyrimido-six-membered ring structure, pharmaceutical compositions comprising same, and use thereof. The compounds have a structure represented by formula (I) below. Experiments prove that the compounds of the present application exhibit significantly excellent inhibitory activity against KRAS-G12C/SOS1 interaction. Therefore, the compounds of formula I have the potential to be an SOS1 inhibitor and can be developed into a drug for treating diseases related thereto.
Inventors:
LI DONGSHENG (CN)
LIU CAILU (CN)
CAI YALEI (CN)
YANG MAOZHI (CN)
TU WANGYANG (CN)
YU BING (CN)
XIE QING (CN)
ZHANG YIXIANG (CN)
LI LEPING (CN)
LIU CAILU (CN)
CAI YALEI (CN)
YANG MAOZHI (CN)
TU WANGYANG (CN)
YU BING (CN)
XIE QING (CN)
ZHANG YIXIANG (CN)
LI LEPING (CN)
Application Number:
PCT/CN2023/101588
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
HAIHE BIOPHARMA CO LTD (CN)
International Classes:
C07D471/04; A61K31/519; A61P35/00; C07D403/12; C07D519/00
Domestic Patent References:
| WO2023067546A1 | 2023-04-27 | |||
| WO2021083936A1 | 2021-05-06 | |||
| WO2021074227A1 | 2021-04-22 | |||
| WO2021228028A1 | 2021-11-18 |
Foreign References:
| CN115785088A | 2023-03-14 | |||
| CN114685488A | 2022-07-01 | |||
| CN105793254A | 2016-07-20 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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